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Increase fertility 300 percent with DHEA?

Posted Jul 03 2010 12:00am

AFTAU.org - A Tel Aviv University study is giving new hope to women concerned with fertility who want to conceive - in the form of a supplement pill, DHEA, already available in drugstores and dietary supplement stores.

Prof. Adrian Shulman of Tel Aviv University’s Sackler Faculty of Medicine and the Meir Medical Center has found a statistical connection between the over-the-counter natural supplement DHEA, often used to try to counter the effects of aging, and successful pregnancy rates in women undergoing treatment for infertility.

In the first controlled study on the effects of the supplement, Prof. Shulman found that women being treated for infertility who also received a DHEA supplement were three times more likely to conceive than women being treated without the supplement - that is a 300 percent improvement. The results were recently published in AYALA, the journal of the Israeli Fertility Association.

A natural supplement to fertility treatments

After hearing anecdotal evidence from his patients and the medical community on the benefits of combining fertility treatments with DHEA, a hormone naturally present in the body, marketed as an anti-aging supplement around the world, Prof. Shulman decided to put this old wives’ tale to the statistical test.

He and his fellow researchers conducted a study in which a control group of women received treatment for poor ovulation, and another group received the same treatment with the addition of the DHEA supplement. The latter group took 75 mg of the DHEA supplement daily for 40 days before starting fertility treatments, and continued for up to five months.

Not only were women who combined infertility treatment with DHEA more likely to conceive, the researchers discovered, they were also more likely to experience a healthy pregnancy and delivery.

“In the DHEA group, there was a 23 percent live birth rate as opposed to a 4 percent rate in the control group,” explains Shulman. “More than that, of the pregnancies in the DHEA group, all but one ended in healthy deliveries.”

Does DHEA help make grade-A human eggs?

Shulman believes that women who are finding little success with their current fertility treatments could look to DHEA to improve their chances of conceiving. “We recommend that women try this DHEA treatment, in conjunction with fertility treatments, for four to five months,” says Prof. Shulman. It could also be used as a regular supplement for women who have already conceived and are pregnant, but more research would need to be done on the compound to determine its effects, says Prof. Shulman.

DHEA, or 5-Dehydroepiandrosterone (5-DHEA), is a naturally-occurring steroid found in the brain, which plays an important biological role in humans and other mammals. Produced in the adrenal glands, it is also synthesized in the brain. The pharmaceutical version of this molecule is known as Prastera, Prasterone, Fidelin and Fluasterone, and identical generics are widely available over the counter in the United States without a prescription. Women interested in using DHEA to conceive, however, should consult their practitioner first, suggests Prof. Shulman, a gynecologist and director of the IVF Unit of the Obstetric and Gynecology Department at Meir Medical Center.

While studies on the effects of DHEA are far from complete - his test group only included around 20 women - Prof. Shulman hopes that further research will unlock the secrets of why the supplement aids in successful conception in women with an otherwise poor response to fertility treatments. “We need to look into what the drug actually does to make the body more fertile,” he says. “It could be affecting components such as the quality of the eggs or the follicles.”

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