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Immortalized Human Bronchial Epithelial Cell Line

Posted Jul 22 2010 5:00pm

Description of Invention:
Normal cells can be cultured in vitro for a limited period of time before they exhibit a "crisis" or senescence, wherein they display abnormal cell morphology and significant reduction or cessation of cell proliferation. Investigators at the National Cancer Institute developed immortalized cell line by isolating bronchial epithelial cells from non-cancerous individuals and subsequent infection with an adenovirus 12-SV40 virus hybrid. Unlike normal cells, the immortalized cells be cultured continuously in vitro in suitable medium and retain features of normal human bronchial epithelial cells, including the absence of invasive behavior in vitro or in vivo. These cells can also be transfected with oncogenes and used as a model for multistage carcinogenesis, or employed to assay a biological or chemical agent's ability to induce differentiation and carcinogenesis as well as test potential chemotherapeutic agents.

Applications:
  • Model to study multistage bronchial carcinogenesis
  • Identification of potential chemotherapeutic drugs
  • Identification of carcinogenic agents


Advantages:
Immortalized cells that retain normal human bronchial characteristics

Inventors:
Curtis C Harris (NCI)


Patent Status:
HHS, Reference No. E-287-1987/0
PCT, Application No. PCT/US88/03267 filed 29 Oct 1988

Research Material -- patent protection is not being pursued for this technology

Relevant Publication:
  1. RR Reddel et al. Transformation of human bronchial epithelial cells by infection with SV40 or adenovirus-12 SV40 hybrid virus, or transfection via stronium phosphate coprecipitation with a plasmid containing SV40 early region genes. Cancer Res. 1988 Apr 1;48(7):1904-1909. [ PubMed: 2450641 ]


Licensing Status:
Available for licensing.

Collaborative Research Opportunity:
The Center for Cancer Research, Laboratory of Human Carcinogenesis, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize Immortalized Human Bronchial Epithelial Cell Line. Please contact John Hewes, Ph.D. at 301-435-3121 or hewesj@mail.nih.gov for more information.


Portfolios:
Cancer
Cancer - Research Materials



For Additional Information Please Contact:
Jennifer Wong
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: wongje@mail.nih.gov
Phone: 301-435-4633
Fax: 301-402-0220


Ref No: 2141

Updated: 07/2010

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