It is tender if I try to rub it and when it came on last week by lower calf hurt also. Like a muscle ache. I had walked for about 30 minutes the day before and this was the first exersize I had done in quite awhile. I have recently lost about 15 pounds but am still needing to lose 20. I have Hashimoto's disease and am taking 55mcg levoxythyroid (?) but other than advil, vitamins and some benadryl that is the only med I am taking. I have had the ache in my thigh for about 5 days now.