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Human Melanoma Metastasis Cell Lines Harboring GRM3 Mutations

Posted Feb 03 2013 7:00pm

Description of Invention:
Using exon capture and next generation sequencing approaches to analyze the entire G protein coupled receptor (GPCR) gene family in melanoma, the researchers at the NIH have identified several novel somatic (e.g., tumor-specific) alterations. GPCRs play an integral part in regulating physiological functions and the importance of these molecules is evident by the fact that approximately half of the current FDA approved therapeutics target GPCRs or their direct downstream signaling components. Many of the GPCR gene mutations identified by the NIH researchers were mutated in a large portion of melanoma patients and already have inhibitors, the most notable being the Glutamate Receptor Metabotropic 3 (GRM3) mutation which could be functionally signification for melanoma tumorigenesis.

Available for licensing are several melanoma cell lines that harbor GRM3 mutations. These cell lines provide useful and efficient tools for studying melanoma and can be used in the development of specific inhibitors of GRM3 as well as the pathway it activates, mitogen-activated protein kinase (MEK), for the treatment of melanoma patients with these mutations.

Applications:
  • Diagnostic array for the detection of GRM3 mutations.
  • Method of identifying GRM3 inhibitors as therapeutic agents to treat malignant melanoma patients.
  • In vitro and in vivo cell model for the GRM3 mutation in melanoma. This is a useful tool for investigating GRM3 phenotype biology, including growth, motility, invasion, and metabolite production.
  • Tool for testing the activity of GRM3 inhibitors and generating GRM3 mutation knock-outs.


Advantages:
  • Cell lines are derived from melanoma patients.
  • GRM3 mutations are highly frequent and/or highly mutated in melanomas.
  • Several inhibitors to GPCR and MEK are already in clinical trials, thus this technology may prove useful for the development of novel diagnostic tests and therapeutics.


Development Status:
Pre-clinical

Inventors:
Yardena R Samuels (NHGRI)
Steven A Rosenberg (NCI)


Patent Status:
HHS, Reference No. E-029-2012/0

Research Tool — Patent protection is not being pursued for the GRM3 melanoma metastatic cell lines.

Related Technologies:
EIR, Reference No. E-244-2012/0 — Research Tool. Patent protection is not being pursued for this technology.
US, Application No. 61/462,471 filed 02 Feb 2011, Reference No. E-013-2011/0
PCT, Application No. PCT/US2012/022687 filed 26 Jan 2012, Reference No. E-013-2011/0
EIR, Reference No. E-024-2012/0 — Research Tool. Patent protection is not being pursued for this technology.
US, Application No. 61/199,156 filed 12 Nov 2008, Reference No. E-272-2008/0
US, Application No. 13/128,125 filed 06 May 2011, Reference No. E-272-2008/0
EIR, Reference No. E-229-2010/0 — Research Tool. Patent protection is not being pursued for this technology.
EIR, Reference No. E-232-2010/0 — Research Tool. Patent protection is not being pursued for this technology.


Relevant Publication:
  1. Prickett TD, et al. [ PMID 21946352 ]


Collaborative Research Opportunity:
The NHGRI is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize this technology. For collaboration opportunities, please contact Claire Driscoll, Director, NHGRI Technology Transfer Office, at cdriscol@mail.nih.gov or 301-594-2235.


For Licensing Information Please Contact:
Whitney Hastings
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: hastingw@mail.nih.gov
Phone: 301-451-7337
Fax: 301-402-0220


Ref No: 2521

Updated: 02/2013

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