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Hspa2 Knockout Mice for Study of Spermatogenesis and Male Infertility

Posted May 03 2012 8:00pm

Description of Invention:
HSPA2 is a member of the HSP70 family of heat-shock proteins that serve as molecular chaperones. Researchers discovered that HSPA2 protein is expressed in spermatogenesis during the meiotic phase. Spermatogenic cells lacking the HSPA2 protein arrest in mid-meiosis and undergo apoptosis. HSPA2 is present in the synaptonemal complex of wild-type mice and the chromosomes fail to separate in HSPA2-deficient mice (previously known as Hsp70-2-/- mice), suggesting that HSPA2 is required for the chromosomal events of meiosis such as synapsis, crossing over, or recombination.

Researchers at NIEHS developed a knockout strain of mice in which the heat shock protein gene (Hspa2) is disrupted. This mouse model is useful in studying the process of spermatogenesis and the influence of various environmental toxins or drugs on sperm production and male infertility.

  • Mouse model to study spermatogenesis and male infertility
  • Mouse model to study meiosis or the roles of heat-shock proteins in general
  • Mouse model to evaluate effects of meiosis-disrupting agents on meiotic recombination and generation of mutations transmitted to offspring

Development Status:
  • In vitro data available
  • In vivo data available (animal)

Edward M Eddy (NIEHS)

Patent Status:
HHS, Reference No. E-052-2011/0

Research Tool — Patent protection is not being pursued for this technology.

Related Technologies:
EIR, Reference No. E-290-2011/0

Research Tool — Patent protection is not being pursued for this technology.

Relevant Publication:
  1. Dix DJ, et al. [ PMID 8622925 ]

Collaborative Research Opportunity:
The NIEHS is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize this mouse strain. For collaboration opportunities, please contact Elizabeth Denholm, Ph.D. at .

For Licensing Information Please Contact:
Lauren Nguyen-Antczak Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-496-7057
Fax: 301-402-0220

Ref No: 2431

Updated: 05/2012

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