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Hormone Reverses Symptoms of Heart Failure

Posted Jun 21 2013 10:08pm
Posted on June 21, 2013, 6 a.m. in Cardio-Vascular Aging

New research has shed light on the underlying causes of age-related heart failure and may lead to the development of new treatment strategies for this extremely debilitating condition. A team of researchers led by Richard Lee and Amy Wagers of the Harvard Stem Cell Institute found that levels of a hormone known as growth differentiation factor 11 (GDF11) were significantly lower in old mice than they were in younger mice. The researchers treated the old mice with GDF11 injections in order to restore the hormone to youthful levels. Results showed that treatment with GDF11 reversed signs of cardiac aging – heart muscle cells became smaller, and the thickness of the heart muscle wall resembled that of young mice. "If some age-related diseases are due to loss of a circulating hormone, then it's possible that restoring levels of that hormone could be beneficial," said Wagers. "We're hoping that some day, age-related human heart failure might be treated this way."

Francesco S Loffredo, Matthew L Steinhauser, Steven M Jay, Joseph Gannon, James R Pancoast, Pratyusha Yalamanchi, Manisha Sinha, Claudia Dall’Osso, Danika Khong, Jennifer L Shadrach, Christine M Miller, Britta S Singer, Alex Stewart, Nikolaos Psychogios, Robert E Gerszten, Adam J Hartigan, Mi-Jeong Kim, Thomas Serwold, Amy J Wagers, Richard T LeeSee.  Growth differentiation factor 11 is a circulating factor that reverses age-related cardiac hypertrophy. Cell. 2013;153:828-839.

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Tip #179 - Swimming in Good Reasons
Researchers from the University of South Carolina (South Carolina, USA) analyzed data collected on 40,547 men, ages 20 to 90 years, for the period 1971–2003. The team found that swimmers had 53%, 50%, and 49% lower all-cause mortality risk than did men who were sedentary, walkers, or runners, respectively. In addition, swimmers demonstrated greater cardiorespiratory fitness than walkers and sedentary people.

Consult your anti-aging physician to assess the level of fitness appropriate to your medical needs; s/he will help design an exercise regimen tailored for you.
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