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High-Tech Grapefruit

Posted Jun 25 2013 10:07pm
Posted on June 24, 2013, 6 a.m. in Bioengineering Drug Delivery Technology

Nanotechnology offers a wide potential for medical therapeutics – specifically with regard to delivery applications. Qilong Wang, from the Louisville Veterans Administration Medical Center (Kentucky, USA), and colleagues have devised nanoparticles made of grapefruit-derived lipids, which the authors referred to as "grapefruit-derived nanovectors,” (GNVs) and find that these molecules  can effectively deliver chemotherapeutic agents, short interfering RNA, DNA expression vectors and proteins to different types of cells. Further, the team reports that treatment of animals with GNVs causes fewer adverse effects, as compared to treatment with drugs encapsulated in synthetic lipids. A Phase 1 clinical trial for treatment of colon cancer patients suggests that GNVs is not only effective, but confers no toxicity. 

Qilong Wang, Xiaoying Zhuang, Jingyao Mu, Zhong-Bin Deng, Hong Jiang, et al. “Delivery of therapeutic agents by nanoparticles made of grapefruit-derived lipids.”  Nature Communications 4, 1867; 21 May 2013.

  
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Anti-Aging Forum MLDP Join A4M
Tip #181 - Stay Stimulated
Researchers from the Mayo Clinic (Minnesota, USA) studied 197 men and women, ages 70 to 89 years, with mild cognitive impairment, or diagnosed memory loss, and 1,124 people that age with no memory problems. Both groups were surveyed as to their daily activities within the past year and in middle age, when they were between 50 to 65 years old. The team report that during later years, reading books, playing games, participating in computer activities and doing craft activities such as pottery or quilting led to a 30 to 50% decrease in the risk of developing memory loss (as compared to people who did not engage in these activities.)

Albert Einstein College of Medicine (New York, USA) researchers studied 488 cognitively healthy men and women, following their habits in engaging in cognitively stimulating leisure activities and charting the onset of accelerated memory decline. The team found that for each additional activity day spent reading, writing, doing crossword puzzles, playing board or card games, engaging in group discussions, or playing a musical instrument, older individuals who eventually developed dementia delayed the onset of accelerated memory decline by more than two months.

Engage in mentally stimulating activities. Crafting, reading books, playing board games, doing a crossword puzzle or Sudoku, and surfing the Internet are not only fun ways to learn new things, but may help protect against future memory loss as well.
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