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Healthy diet linked to ovarian cancer survival

Posted Mar 08 2010 12:00am

Often diagnosed in late stages, ovarian cancer has an asymptomatic onset and a relatively low 5-year survival rate of about 45 percent. But there is some good news about the positive impact that a healthy diet can have on ovarian cancer survival rates. Researchers from the University of Illinois at Chicago determined that there is a strong relationship between healthy eating and prolonged survival. Their study was published in the March 2010 issue of the Journal of the American Dietetic Association.

The subjects included 351 women diagnosed with incident epithelial ovarian cancer who participated in a previous case-control study. The original study collected demographic, clinical, and lifestyle-related variables including diet. Each subject completed a food frequency questionnaire (FFQ) where they were asked to report their usual dietary intake over the three to five years prior to their diagnosis.

To interpret the diet estimates in a meaningful way, the FFQ items were assigned to the major food groups reflected in the Dietary Guidelines for Americans 2005 (DGA), including fruits, vegetables, grains, meats, dairy, fats and oils, sweets, and alcohol. Grains, meats, and dairy were further subdivided to “suggested” and “other” groups. The “suggested” subdivisions included healthier food choices, whereas the “other” subdivisions contained less desirable selections.

The authors found that higher total fruit and vegetable consumption, and higher vegetable consumption alone led to a survival advantage. Likewise, a statistically significant improvement in survival was observed for the healthier grains. Higher intakes of less-healthy meats were associated with a survival time disadvantage.

The authors state, “The study findings suggest that food patterns three to five years prior to a diagnosis of epithelial ovarian cancer have the potential to influence survival time. The pre-diagnosis food patterns observed to afford a survival advantage after an epithelial ovarian cancer diagnosis reflect characteristics commonly found in plant-based or low fat diets. These diets generally contain high levels of constituents that would be expected to protect against cancer and minimize ingestion of known carcinogens found in foods.”

An editorial commentary in the same issue states, “The authors provide new evidence that dietary factors, particularly total fruit and vegetable, red and processed meat and milk intakes, may influence ovarian cancer survival. These findings corroborate earlier work by Nagle et al and are among only a select few studies of dietary associations with ovarian cancer recurrence and/or prognosis despite a significant and growing body of literature suggesting diet may influence ovarian cancer risk” (Courtesy of EurekAlert!, a service of AAAS).

References: “Pre-diagnosis Food Patterns Are Associated with Length of Survival from Epithelial Ovarian Cancer” by Therese A. Dolecek, PhD, et al. The commentary is “Diet and Survival After Ovarian Cancer: Where are We and What’s Next?” by Cynthia A. Thomson, PhD, RD, and David S. Alberts, MD. Both appear in the Journal of the American Dietetic Association, Volume 110, Issue 3 (March 2010).

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