Eating grapes may offer some protection against heart failure caused by high blood pressure. E. Mitchell Seymour, Ph.D., and colleagues at the University of Michigan Health System fed hypertensive, heart failure-prone rats a grape-enriched diet for 18-weeks. Their results confirmed earlier findings showing that grape consumption reduced heart muscle enlargement and fibrosis, and improved the diastolic function of the heart. However, in this NIH-funded study the researchers were able to determine the mechanism behind these benefits. Results showed that grape consumption “turned on" antioxidant defense pathways, by increasing the activity of related genes that boost production of glutathione, the most abundant cellular antioxidant in the heart. "Our earlier studies showed that grapes could protect against the downward spiral of hypertensive heart failure, but just how that was accomplished – the mechanism – was not yet known," said lead investigator E. Mitchell Seymour, Ph.D. "The insights gained from our NIH study, including the ability of grapes to influence several genetic pathways related to antioxidant defense, provide further evidence that grapes work on multiple levels to deliver their beneficial effects." "Our earlier studies showed that grapes could protect against the downward spiral of hypertensive heart failure, but just how that was accomplished – the mechanism – was not yet known," said Dr Seymour. "The insights gained from our NIH study, including the ability of grapes to influence several genetic pathways related to antioxidant defense, provide further evidence that grapes work on multiple levels to deliver their beneficial effects."
E Mitchell Seymour, Maurice R Bennink, Steven F Bolling. Diet-relevant phytochemical intake affects the cardiac AhR and nrf2 transcriptome and reduces heart failure in hypertensive rats. J Nutr Biochem. 2013 Mar 22.[Epub ahead of print]
Unwanted gray hair may soon be a thing of the past thanks to a new compound that reverses oxidative stress in the hair follicle.
Switching off a hormone found in fat cells has been shown to improve control of glucose production by the liver.
Eating walnuts or walnut oil can reduce the risk of cardiovascular disease by improving blood vessel function and helping to remove cholesterol from the body.
Increasing the expression of a gene previously linked to Parkinson’s disease has be shown in increase the lifespan of fruit flies by as much as 25%.
Grapes have been found to reduce heart failure associated with chronic high blood pressure.
A study on mice suggests that the hypothalamus may control aging throughout the body.
Research suggests that exercise reduces a woman’s breast cancer risk by increasing the production of “good” estrogen metabolites.
Researchers find that a lack of melatonin is associated with the progression of an animal model of the neurodegenerative disease amyotrophic lateral sclerosis.
Playing a mental agility computer game has been shown to slow cognitive decline in older people.
People taking selective antidepressants around the time of having surgery are found to have an increased risk of bleeding, transfusion, readmission, and death.
A group of researchers from Israel claim to have established an upper safe limit for vitamin D, the so-called sunshine vitamin.
Naturopathic therapies in conjunction with usual care may reduce a person’s risk factors for heart disease.
Heart failure costs are projected to more than double in the next 20 years, as the US population ages and the incidence of the condition climbs.
Elevated hair cortisol levels over time may correlate to an increased risk of cardiovascular disease.
Easily distressed individuals may be at higher risk of heart disease.
Long-term exposure to fine particles of traffic pollution may increase a person’s risk of heart disease.
A high heart rate may be an independent risk factor for mortality, among fit men.
A diet rich in antioxidants may reduce a woman’s risk of heart failure by 42%.
Stroke and subclinical markers of vascular disease may be predicative of those older patients with type 2 diabetes who may develop cognitive decline.
Diets laden with fried and sweet foods, processed and red meats refined grains, and high-fat dairy products reduce a person's likelihood of achieving older ages
Tip #175 - Circumvent A Cold
Researchers from Carnegie Mellon University (Pennsylvania, USA) studied 153 healthy men and women, ages 21 to 55 years, who reported daily on their sleep duration and quality for two weeks. Participants were then quarantined in separate rooms for 5 days and exposed to rhinovirus (the virus that is responsible for the common cold). As a result, 35.3% of subjects developed a clinical cold and 43.1% self-reported the presence of cold symptoms. The researchers found that those study subjects with shorter duration of sleep and poorer sleep efficiency were at significantly increased risk of developing a cold.
The restorative role of sleep is often underestimated. In that too little sleep has been found to compromise many of the body’s biological processes, including immune function, be sure to achieve sleep of a sufficient duration that is followed by a spontaneous awakening and leaves you feeling refreshed and alert for the day.