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GPR116 Knockout and Conditional Knockout Mice

Posted Jun 17 2013 8:00pm

Description of Invention:
Pulmonary surfactant plays a critical role in preventing alveolar collapse by decreasing surface tension at the alveolar air-liquid interface. Surfactant deficiency contributes to the pathogenesis of acute lung injury (ALI) and acute respiratory distress syndrome (ARDS), common disorders that can afflict patients of all ages and carry a mortality rate greater than 25%. Excess surfactant leads to pulmonary alveolar proteinosis. The NCI investigators created a G-protein coupled receptor GPR116 mutant mouse model and showed that GPR116 plays a previously unexpected, essential role in maintaining normal surfactant levels in the lung.

The mouse model could aid in the development of drug screens to identify agents that can modulate surfactant levels. Alveolar type II cells have also been isolated from the GPR116 wildtype and knockout mice that could be directly used in such assays. The identification of surfactant modulating agents could be important to a number of lung surfactant disorders.

Applications:
Research materials to study lung surfactant homeostasis and disorders.

Advantages:
Not available elsewhere.

Development Status:
  • Prototype
  • Pre-clinical
  • In vitro data available
  • In vivo data available (animal)


Inventors:
Brad D St. Croix (NCI)
Mi Young Yang (NCI)


Patent Status:
HHS, Reference No. E-269-2012/0

Research Tool – Patent prosecution is not being pursued for this technology.

Relevant Publication:
  1. Yang MY, et al. [ PMID 23684610 ]


Collaborative Research Opportunity:
The Center for Cancer Research Mouse Cancer Genetics Program is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate or commercialize GPR116 Knockout and Conditional Knockout Mice. For collaboration opportunities, please contact John Hewes, Ph.D. at hewesj@mail.nih.gov .


For Licensing Information Please Contact:
Betty Tong Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: tongb@mail.nih.gov
Phone: 301-594-6565
Fax: 301-402-0220


Ref No: 2575

Updated: 06/2013

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