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Posted Mar 14 2013 4:23am
Effect of Not Sleeping on Health
“According to a new study published by the Proceedings of the National Academy of Sciences, just one week of abnormal, insufficient sleep is enough to dramatically alter the activity of human genes.” One night without sleep can make you feeling tired the whole day and yawning will probably annoy you and the people around. How about two nights of no sleeping or three? It will surely make you cranky and restless. But just a week of not enough sleep can radically change the activity of human genes. The genes that will be affected are associated with controlling response to stress, immunity, and inflammation. After a week of pitiable sleep the number of genes influenced by sleep deprivation is seven times greater. Obesity, cognitive impairment, heart disease are just few of the complications of not having enough sleep.
According to the Centers for Disease Control and Prevention, USA, sleep deprivation and sleep disorders affect from 50 to 70 million people in America thus making sleep disorders very common. But until recently, scientists were unaware how gene expression patterns were modified by poor sleep. These ‘gene expression’ patterns offer critical clues on the possible molecular mechanisms that connect sleep with total health. The genes affected by poor sleep were linked to circadian rhythms, metabolism, and sleep homeostasis.
Macromolecular metabolism, gene-expression regulation, chromatin modification, inflammatory responses, immune responses, stress responses, these are the biological processes that the investigators found as being affected. The biological processes recognized may be involved with the negative results of poor sleep on health and stress the links between sleep homeostasis, circadian rhythmicity, and metabolism.
Springhill Medical Korea Raises Asian Standard in AMI Treatment | SHELFARI
The Korean Society of Interventional Cardiology (KSIC, www.ksic.org) and the Korean Society of Cardiology (KSC) presented a roadmap to improve treatment results and establish an Asian treatment standard for AMI during a symposium titled 'Raising Asia Standard,' held yesterday in the Grand Hyatt Seoul, Korea. Korea's 30-day AMI in-hospital mortality rate reached 6.9% in 2011. In terms of age-sex standardized OECD mortality in 2009, the rate was still 6.3%, far higher than in Australia (3.2%), the US (4.3%) and Denmark (2.3%) as well as the OECD average (5.4%). But, it was lower than in Japan (9.7%) and Singapore (8.2%).1
In addition, Korea's AMI mortality within one year after hospital discharge was 8.1% in 2010, so well-established management for AMI patients is needed. OECD said that Korea should improve its health system to increase the quality of medical services. In a report titled 'OECD Health Care Quality Review: Korea,' published in February 2012, OECD emphasized the improvement of quality of care for cardiovascular diseases by establishing registration for patients at risk in order to deliver long term monitoring services and follow-up services.
"The RAS campaign will provide an opportunity to help streamline the emergency medical system and improve the quality of healthcare services across all AMI treatment areas in Korea," said KSIC Chairman Jang Yang-soo. "I hope that this campaign, which started in Korea, will help advance healthcare services across Asia and save more AMI patients' lives."