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Gila Monster Drug Curbs Food Cravings

Posted Jun 20 2012 10:09pm
Posted on June 19, 2012, 6 a.m. in Weight and Obesity |
Gila Monster Drug Curbs Food Cravings

The drug Exenatide, which is used by people with type 2 diabetes to help them control their blood glucose levels is a synthetic version of a natural substance called exendin-4, which is obtained from the saliva of the Gila monster lizard. Research on rats by Assistant Professor Karolina Skibicka at the Sahlgrenska Academy at the University of Gothenburg (Sweden) and colleagues showed that exendin-4 significantly reduced their food intake, thus suggesting that it curbs cravings for food.  As well as curbing appetite, the findings suggest that exendin-4 may be useful in the treatment of addictions as the researchers showed that the substance affects the reward and motivation regions of the brain.

Suzanne L Dickson, Rozita H Shirazi, Caroline Hansson, Filip Bergquist, Hans Nissbrandt, Karolina P Skibicka. "The glucagon-like peptide 1 (GLP-1) analogue, exendin-4, decreases the rewarding value of food: a new role for mesolimbic GLP-1 receptors." J Neurosci. 2012;32:4812-4820.

  
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293. Of Thoughtful Benefit
Meditation is a technique utilized to focus the mind, often accompanied by a calming or stress-reducing effect. Such mental training has garnered the interest of the scientific community, with data suggesting that meditation may:
• Slow Age-Related Brain Changes: Researchers at the University of California/Los Angeles (UCLA; California, USA) report that people who meditate display stronger connections between brain regions and show less age-related brain atrophy. Having stronger connections influences the ability to rapidly relay electrical signals in the brain. And significantly, these effects are evident throughout the entire brain, not just in specific areas. The greatest differences between meditators vs non-meditators were seen within the corticospinal tract...
 
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