The June 2007 issue of Chest reported more than half of the patients with advanced COPD (chronic obstructive pulmonary disease) have GERD (gastroesophageal reflux disease). The overall presence of GERD was 57% in this small 42 patient study. Only 26% reported heartburn or acid indigestion. Most were not recieving acid blockers at the time of their referral to the University of Minnesota School of Medicine. Even though they did not advise routine screening for GERD in emphysema, I do. An even more recent study confirmed a positive correlation involving GERD worsening breathing problems. From MEDSCAPE, "NEW YORK (Reuters Health) Nov 26, 2008 - Results of a study published in the November issue of Thorax suggest that symptoms of gastroesophageal reflux disease (GERD) are an important factor associated with exacerbations in chronic obstructive pulmonary disease (COPD)."