Time-line of futility?? Where is the NIH? You NEVER hear a TV commercial for acid blockers to treat asthma...just keep using steroids, airway stimulants, mucus thinners, antihistamines, anti-inflammatories and "inhalers" to TREAT SYMPTOMS of asthma
Late 1800’s….Sir William Osler on night time asthma…“attacks may be due to direct irritation of bronchial mucosa or…indirectly, too, by reflex influences from the stomach”.
1934, Bray proposed reflex mediated bronchoconstriction through the vagus nerve.
1962, “Silent Gastroesophageal Reflux: An Important but little Known Cause of Pulmonary Complications” by J.H. Kennedy, Diseases of the Chest.
1999, “Gastroesophageal Reflux Disease and Airway Disease” edited by Dr. Mark R. Stein.
2002, “Are You Sick of Being Sick?” authored by Dr. Kurt A Barrett.