Health knowledge made personal
Join this community!
› Share page:
Search posts:

Genetics of Coronary Artery Disease Revealed

Posted Dec 25 2012 10:06pm
Posted on Dec. 24, 2012, 6 a.m. in Genetics in Disease Cardio-Vascular Inflammation

Coronary artery disease (CAD) is the leading cause of death, both in the United States and many other developed nations.   The CARDIoGRAMplusC4D Consortium, comprised of over 170 researchers, has identified fifteen new genetic regions associated with CAD, providing insights into the molecular pathways causing coronary artery disease, which is also known as coronary atherosclerosis. The massive meta-analysis combined genetic data from over 190,000 research participants and utilized the technique of genome-wide association studies (GWAS), that scans the entire genome to identify differences in the DNA code, or "polymporphisms," that predispose people to various common but genetically complex diseases.   Interestingly, about a quarter of the genetic regions associated with coronary disease or heart attack were also found to be strongly associated with cholesterol, especially high levels of the so-called bad cholesterol known as LDL. Another 10% were associated with high blood pressure. Both of these conditions are known risk factors for coronary artery disease. Observing that: “The four most significant pathways mapping to these networks are linked to lipid metabolism and inflammation, underscoring the causal role of these activities in the genetic etiology of [coronary artery disease],” the study authors conclude that: “ Our study provides insights into the genetic basis of [coronary artery disease] and identifies key biological pathways.”

The CARDIoGRAMplusC4D Consortium.  “Large-scale association analysis identifies new risk loci for coronary artery disease.”  Nat Genet. 2012 Dec 2.

To maintain healthy weight at the holidays, think twice before reaching for traditional staples like cookies or candy – and the car keys.
Mercury released into the air and then deposited into oceans contaminates seafood eaten by people worldwide.
Higher vitamin D dietary intake associates with a lower risk of developing Alzheimer's disease, among women.
Fifteen new genetic regions associated with coronary artery disease have been identified by a large, international consortium of scientists.
A symbol of Christmas, mistletoe has the potential to play a vital role as an alternative therapy for people affected by colon cancer.
Improving the ability of people affected by Parkinson's Disease to pedal on a stationary bike may strengthen connectivity in brain regions tied to motor functio
An active lifestyle helps preserve gray matter in the brains of older adults and could reduce the burden of dementia and Alzheimer's disease.
Canadian team transforms aged stem cells into cardiac tissue.
Baked goods help to reduce blood pressure levels, in people affected by peripheral artery disease.
Variation in low-level natural background radiation may exert a small, but significant, negative effects on DNA as well as several measures of health.
German team reports that DNA methylation is altered by acute stress, thereby affecting the activity of genes.
A shorter length of telomeres associated with a 21% increased risk of dementia.
The erosion of protective telomere caps, with subsequent enzymatic activation, promotes the ability of prostate cancer cells to become more deadly.
Research has shown that it is possible to favorably modify a gene with a strong link to heart disease by eating a diet containing plenty of fruit and vegtables.
Researchers have uncovered 3 genes that significantly increase the risk of developing melanoma.
King's College (UK) team identifies a gene linked to diabetes and cholesterol that may be the "master regulator" gene that controls the behavior of other genes
Eight genes that control levels of the hormone DHEAS, thought to play a key role in longevity, have been identified by a international group of scientists.
Short telomeres, the endcaps of chromosomes, may predispose people to age-related diabetes.
Parental history of heart attack trumps traditional risk factors in predicting a person’s odds of having a myocardial infarction.
European team reports that a daily cup of coffee helps to minimize the oxidative damage to DNA.
Anti-Aging Forum MLDP Join A4M
#94 - Breathe Easy
People spend about 90% of their time indoors. Consequently. the risks to health may be greater due to exposure to air pollution indoors that outdoors. Cut down on indoor triggers of allergies and asthma by following these simple tips:
• Remove pets from the home and thoroughly clean to eliminate their dander.
• Opt for leather furniture rather than upholstered pieces, since leather is an impervious material that is resistant to breeding dust mites.
• Eliminate carpet and drapes.
• Dust both vertical and horizontal surfaces weekly.
• Keep indoor humidity below 50% year round.
• Open windows for an hour each day during dry seasons to improve ventilation.
• Clean mold off shower curtains, bathroom and basement walls and other surfaces with a solution of bleach, detergent and water.
• Use a dehumidifier if your basement is damp or musty.
• Never allow smoking in the house.
Post a comment
Write a comment:

Related Searches