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Genetics of Coronary Artery Disease Revealed

Posted Dec 25 2012 10:06pm
Posted on Dec. 24, 2012, 6 a.m. in Genetics in Disease Cardio-Vascular Inflammation

Coronary artery disease (CAD) is the leading cause of death, both in the United States and many other developed nations.   The CARDIoGRAMplusC4D Consortium, comprised of over 170 researchers, has identified fifteen new genetic regions associated with CAD, providing insights into the molecular pathways causing coronary artery disease, which is also known as coronary atherosclerosis. The massive meta-analysis combined genetic data from over 190,000 research participants and utilized the technique of genome-wide association studies (GWAS), that scans the entire genome to identify differences in the DNA code, or "polymporphisms," that predispose people to various common but genetically complex diseases.   Interestingly, about a quarter of the genetic regions associated with coronary disease or heart attack were also found to be strongly associated with cholesterol, especially high levels of the so-called bad cholesterol known as LDL. Another 10% were associated with high blood pressure. Both of these conditions are known risk factors for coronary artery disease. Observing that: “The four most significant pathways mapping to these networks are linked to lipid metabolism and inflammation, underscoring the causal role of these activities in the genetic etiology of [coronary artery disease],” the study authors conclude that: “ Our study provides insights into the genetic basis of [coronary artery disease] and identifies key biological pathways.”

The CARDIoGRAMplusC4D Consortium.  “Large-scale association analysis identifies new risk loci for coronary artery disease.”  Nat Genet. 2012 Dec 2.

  
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#94 - Breathe Easy
People spend about 90% of their time indoors. Consequently. the risks to health may be greater due to exposure to air pollution indoors that outdoors. Cut down on indoor triggers of allergies and asthma by following these simple tips:
• Remove pets from the home and thoroughly clean to eliminate their dander.
• Opt for leather furniture rather than upholstered pieces, since leather is an impervious material that is resistant to breeding dust mites.
• Eliminate carpet and drapes.
• Dust both vertical and horizontal surfaces weekly.
• Keep indoor humidity below 50% year round.
• Open windows for an hour each day during dry seasons to improve ventilation.
• Clean mold off shower curtains, bathroom and basement walls and other surfaces with a solution of bleach, detergent and water.
• Use a dehumidifier if your basement is damp or musty.
• Never allow smoking in the house.
 
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