Health knowledge made personal
Join this community!
› Share page:
Go
Search posts:

Gene Therapy Reverses Symptoms of Parkinson’s Disease

Posted Apr 03 2011 12:00am
Posted on 2011-04-01 06:00:00 in Gene Therapy | Parkinsons Disease |

In the first successful randomized, double-blind clinical trial of a gene therapy for Parkinson's or any neurologic disorder, Dr. Michael Kaplitt, from Weill Cornell Medical College (New York, USA), and colleagues introduced a gene into the brain to normalize chemical signaling.  Forty-five patients with moderate to advanced Parkinson's disease who were not adequately controlled with current therapies were enrolled in a  double-blind trial, with half randomized to receive the gene therapy and the other half to a "sham surgery" -- a mock procedure designed to make patients think they could have received the experimental approach. Half of patients receiving gene therapy achieved dramatic symptom improvements, compared with just 14% in the control group. Overall, patients receiving gene therapy had a 23.1% improvement in motor score, compared to a 12.7% improvement in the control group.  The researchers observe that: “The efficacy and safety of bilateral infusion of AAV2-GAD in the subthalamic nucleus supports its further development for Parkinson's disease and shows the promise for gene therapy for neurological disorders.”

Peter A LeWitt et al. “AAV2-GAD gene therapy for advanced Parkinson's disease: a double-blind, sham-surgery controlled, randomised trial.” The Lancet Neurology, The Lancet Neurology, Volume 10, Issue 4, Pages 309 - 319, April 2011.


The Chinese wellness practice of Tai Chi is an important adjunctive therapy that improves quality of life among seniors affected by depression.
A gene therapy called NLX-P101 dramatically reduces movement impairment in Parkinson's patients.
German team reports that a liquid extract from black elderberry may inhibit the growth of pathogenic bacteria involved in upper respiratory tract infections.
High blood pressure (hypertension) is linked to a greater drop in average walking speeds in older adults, potentially impacting a senior's ability to remain fun
Pan-European study reports that a daily dose of olive oil may boost levels of an antibody that counters oxidized LDL (“bad”) cholesterol.
Fine particulate matter in the air may trigger heart abnormalities among middle-age people who do not otherwise have cardiovascular conditions.
Women who drink coffee daily may be at a reduced risk for stroke.
Extract from the red Nordic lingonberry may decrease the body’s total oxidant status and boost antioxidant defense enzymes.
Northwestern University (US) scientists turn human embryonic stem cells in to a type of brain cell that is lost in Alzheimer's disease.
Regrowth of key adult brain cells (neurogenesis) is linked to the benefits of exercise as a stress reducer.

  
View Current Anti-Aging Newsletter!
Second Opinion with Dr. Ron Klatz Solutions to improve your life, and your lifespan too.
radio tower Dr. Ronald Klatz, A4M physician founder, interviews the world’s top anti-aging experts in health, longevity, brain fitness, aesthetic beauty, and more. Get the answers to look and feel twenty years younger today.
Tune in to Second Opinion with Dr. Ronald Klatz. »
U.S. Events
congresses
Orlando Anti-Aging Conference Event
symposiums
workshops
  • Bio-Identical Hormone Replacement Therapy (BHRT) Symposium
  • Integrative Approaches to Practice Development
workshops
Workshops
  • Practice Management Workshop
fellowships
fellowships
International Events

 
Post a comment
Write a comment: