Description of Invention: Because chemical protection (chloroquine) and mosquito control have not adequately reduced deaths from malaria, especially in rural Africa, an anti-malaria vaccine is very desirable. Vaccines have been developed that protect against mosquito-induced infection of humans, which occurs in the sporozoitic stage of the life cycle of the parasite, Plasmodium falciparum. A vaccine may be prepared from the antigen of this invention that will protect against the sexual stage of the parasite's development, preventing the parasite from reproducing when it has been transmitted from a vaccinee to a mosquito. Use of the vaccine should considerably extend the protective immunity conferred by sporozoitic-stage vaccines.
Inventors: Louis H Miller (NIAID) David C Kaslow (NIAID)