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Gene for Encoding a Human Malaria Vaccine Antigen

Posted Feb 27 2011 7:00pm

Description of Invention:
Because chemical protection (chloroquine) and mosquito control have not adequately reduced deaths from malaria, especially in rural Africa, an anti-malaria vaccine is very desirable. Vaccines have been developed that protect against mosquito-induced infection of humans, which occurs in the sporozoitic stage of the life cycle of the parasite, Plasmodium falciparum. A vaccine may be prepared from the antigen of this invention that will protect against the sexual stage of the parasite's development, preventing the parasite from reproducing when it has been transmitted from a vaccinee to a mosquito. Use of the vaccine should considerably extend the protective immunity conferred by sporozoitic-stage vaccines.

Louis H Miller (NIAID)
David C Kaslow (NIAID)

Patent Status:
HHS, Reference No. E-122-1988/0
PCT, Application No. PCT/US89/01618 filed 20 Apr 1989

International filings, patents issued in Belgium, Israel, Australia, Canada, France, Germany, Italy, Japan, United Kingdom, Luxembourg, Austria, Netherlands, Sweden, Switzerland

Infectious Diseases
Infectious Diseases - Vaccines
Rare Diseases

For Licensing Information Please Contact:
Admin. Licensing Spec-InfectDis
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-496-7057
Fax: 301-402-0220

Ref No: 1189

Updated: 02/2011

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