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Freshwater Creature’s Immortality & Secrets of Human Aging

Posted Dec 05 2012 10:09pm

The Hydra, a freshwater organism, has an unlimited lifespan, due in large part to the indefinite self-renewal capacity of its stem cells. Anna-Marei Boehm, from Christian-Albrechts-University (Germany), and colleagues identified the transcription factor forkhead box O (FoxO) as one of the critical drivers of this continuous self-renewal. Specifically, FoxO overexpression he caused signs of aging, specifically in immune function; whereas FoxO  down-regulation led to an increase in the number of terminally differentiated cells – resulting in a drastically reduced population growth rate, and caused down-regulation of stem cell genes and antimicrobial peptide (AMP) expression. Submitting that this data "demonstrates for the first time that there is a direct link between the FoxO  gene and aging, the study authors submit that: "These findings … indicate an evolutionarily conserved role of FoxO in controlling longevity [with] implications for understanding cellular aging.”

Anna-Marei Boehm, Konstantin Khalturin, Friederike Anton-Erxleben, Georg Hemmrich, Ulrich C. Klostermeier, Javier A. Lopez-Quintero, et al.  “FoxO is a critical regulator of stem cell maintenance in immortal Hydra.” PNAS 2012 109 (48) 19697-19702; November 12, 2012.

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Anti-Aging Forum MLDP Join A4M
#82 - Sin of the Skin #6: Dull Skin
Up to the age of 14, the skin on the face exfoliates naturally every 14 days. This quick rate of renewal leaves the youngster with a healthy-looking glowing complexion. However, as we get older the rate of natural exfoliation slows down. By the age of 25 and over the skin will exfoliate every 28 days or so. The resulting build up of dead skin cells can leave the skin looking dull. Establish a twice-daily skin routine of cleansing, toning, and moisturizing. Look for products that contain alpha and beta hydroxy acids (AHAs and BHAs), because they can help promote the natural process of exfoliation. Those with sensitive skin may wish to opt for products containing poly hydroxy acid (PHA), as it is non-irritating.
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