Description of Invention: This invention provides a model for studying human bone metabolism in vivo. The model system can be used to screen compounds which inhibit or stimulate bone formation. A protocol using human marrow stromal fibroblasts is also presented. Use of the protocol results in the formation of self-maintained human bone which supports hematopoiesis. The marrow stromal fibroblasts combined with the described delivery vehicles can be implanted into humans to augment bone implants or to repair bone defects.
Applications: * model for studying human bone physiology and diseases
* forming bone in mammals
* screening a compound for effect on human bone growth
* augmentation of bone defects
Advantages: * model exhibits formation of a complete bone/bone marrow organ
* protocol stimulates bone regeneration in vivo
Inventors: Pamela G Robey (NIDCR)
Patent Status: HHS, Reference No. E-159-1996/0
Relevant Publication:
SA Kuznetsov, PH Krebsbach, K Satomura, J Kerr, M Riminucci, D Benayahu, PG Robey: Single-colony derived strains of human marrow stromal fibroblasts form bone after transplantation in vivo. J Bone Miner Res. 1997 Sep;12(9):1335-1347. [ PubMed abs ]
PH Krebsbach, SA Kuznetsov, K Satomura, RV Emmons, DW Rowe, PG Robey: Bone formation in vivo: Comparison of osteogenesis by transplanted mouse and human marrow stromal fibroblasts. Transplantation 1997 Apr 27;63(8):1059-1069. [ PubMed abs ]
Licensing Status: Available for licensing.
Portfolios: Internal Medicine Internal Medicine - Therapeutics Internal Medicine - Other In-vivo Data
For Additional Information Please Contact: Charlene Sydnor Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: sydnorc@mail.nih.gov Phone: 301-435-4689 Fax: 301-402-0220
Description of Invention:
This invention provides a model for studying human bone metabolism in vivo. The model system can be used to screen compounds which inhibit or stimulate bone formation. A protocol using human marrow stromal fibroblasts is also presented. Use of the protocol results in the formation of self-maintained human bone which supports hematopoiesis. The marrow stromal fibroblasts combined with the described delivery vehicles can be implanted into humans to augment bone implants or to repair bone defects.
Applications:
* model for studying human bone physiology and diseases * forming bone in mammals * screening a compound for effect on human bone growth * augmentation of bone defects
Advantages:
* model exhibits formation of a complete bone/bone marrow organ * protocol stimulates bone regeneration in vivo
Inventors:
Pamela G Robey (NIDCR)
Patent Status:
HHS, Reference No. E-159-1996/0
Relevant Publication:
Licensing Status:
Available for licensing.
Portfolios:
Internal Medicine
Internal Medicine - Therapeutics
Internal Medicine - Other
In-vivo Data
For Additional Information Please Contact:
Charlene Sydnor Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: sydnorc@mail.nih.gov
Phone: 301-435-4689
Fax: 301-402-0220
Ref No: 329
Updated: 06/2010