The World Health Organization reports that in 2008 there were more than 1.4 billion obese adults in the world and that cancer claimed the lives of 7.6 million that year. Whereas a number of previous studies have demonstrated a link between obesity and certain cancer, the physiological causes have not been identified. Mikhail Kolonin, from, The University of Texas Health Science Center at Houston (Texas, USA), and colleagues completed a study in which adipose stromal cells were transplanted into mice; they observed these cells to become recruited by tumors, where they incorporate into blood vessels and become fat cells. The researchers also observed that cancer induces a six-fold increase of adipose stromal cell frequency in the systemic circulation – where they are incorporated into blood vessels as pericytes and they can differentiate into adipocytes in an obesity-dependent manner. The study authors conclude that: “our results suggest that [adipose stromal cells] recruited from endogenous adipose tissue can be recruited by tumors to potentiate the supportive properties of the tumor microenvironment."
Yan Zhang, Alexes C. Daquinag, Felipe Amaya-Manzanares, Olga Sirin, Chieh Tseng, Mikhail G. Kolonin. “Stromal Progenitor Cells from Endogenous Adipose Tissue Contribute to Pericytes and Adipocytes That Populate the Tumor Microenvironment.” Cancer Res., October 15, 2012.
Increased dietary consumption of fish may lower stroke risk by up to 13%.
International Agency for Research on Cancer reports that cancer caused 7.6 million deaths in 2008, but its greater burden is in disability-adjusted life-years
Laboratory model supports theory that fat tissue creates an environment that is promotes tumor growth.
Eating a diet laden with carbohydrates raises the risk of developing mild cognitive impairment by four times; sugars raise that risk 1.5 times.
A strong social network, good self esteem, and a purpose in life correlate with increased bone mineral density.
Increased blood levels of Vitamin B-6 and Coenzyme Q10 associate with a reduced risk of coronary artery disease.
Analysis of data collected on 14,641 male physicians reveals the cancer preventive effect of long-term daily multivitamin supplementation.
University students who chew gum self-report reduced stress levels and greater productivity.
Soccer (football outside the US) helps men with high blood pressure to improve their fitness, normalize their blood pressure. and reduce their risk of stroke.
Found in green leafy vegetables, increased consumption of phylloquinone (Vitamin K1) may lower the risk of developing type-2 diabetes by as much as 51%.
Interleukin-6 (IL-6), a chemical messenger in our immune system, may also trigger weight loss.
New research suggests that exercising for just 30 minutes is as effective for weight loss as a whole hour.
Exposure to a compound produced when food is cooked with dry heat has been linked to the development of abdoinal obesity, and type 2 diabetes in mice.
Drinking three cups of green tea each day shown to help elderly people with metabolic syndrome lose weight and trim their waistline.
Among overweight men who lost weight, the prevalence of hypogonadism (testosterone deficiency) decreased by almost 50%.
Long-term testosterone replacement therapy helped obese hypogonadal men lose an average of 36 pounds, and shed 3.5 inches from their waistline.
People who tend to carry excess weight around their middle have an increased risk of sudden cardiac death, say researchers.
Sleeping for more than nine hours a night may help to suppress some genetic factors that promote weight gain.
Impairment of Rev-Erb alpha, the gene responsible for the body’s internal clock, may prompt weight gain.
Danish study data reveals that an increase in BMI of 4 kg/m2 in life increases the risk of developing heart disease by 50%.
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#72 - Sin of the Skin #3: Thin Skin
As we age, the skin becomes papery thin, and suffers from a decrease in oil gland activity (which also may cause skin to become dry). Largely a function of hormonal decline, you may benefit from a hormone replacement regimen. Consult an anti-aging physician, who will follow these guiding principles to design your hormone replacement therapy (HRT) regimen:
• Use natural, not synthetic, agents
• Select bioidentical hormones, which the body is able to use safely and efficiently
• Prescribe proper dosing (as stipulated by laboratory testing for deficits), not supraphysiologic dosing
• Conduct regular follow-up office visits and lab tests, to monitor progress