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Extra-virgin olive oil polyphenols protect liver from toxicity

Posted Nov 01 2010 12:00am

Extra-virgin olive oil (EVOO) can protect the liver from oxidative stress. Researchers writing in BioMed Central’s open access journal Nutrition and Metabolism exposed rats to a moderately toxic herbicide known to deplete antioxidants and cause oxidative stress, finding that those rats fed a diet containing either extra virgin olive oil or the water-soluble fraction of EVOO - high in natural polyphenols, or phenolics - were partially protected from the resulting liver damage.

Mohamed Hammami from the University of Monastir, Tunisia and King Saud University, Riyadh, Saudi Arabia, worked with a team of researchers to carry out the experiments in a group of 80 rats. He said, “Olive oil is an integral ingredient in the Mediterranean diet. There is growing evidence that it may have great health benefits including the reduction in coronary heart disease risk, the prevention of some cancers and the modification of immune and inflammatory responses. Here, we’ve shown that extra virgin olive oil and its extracts protect against oxidative damage of hepatic tissue.”

The researchers separated the rats into a control group, an extra virgin olive oil group, and 6 groups that were exposed to the herbicide ‘2,4-Dichlorophenoxyacetic acid’ with or without either whole olive oil, or one of two oil extracts – the hydrophilic fraction (water-soluble fraction) or the lipophilic fraction (lipid soluble fraction). All rats given the herbicide showed signs of significant liver damage. However, extra virgin olive oil and hydrophilic fraction intake induced a significant increase in the tissue’s own antioxidant enzyme activity and a decrease in markers of liver damage.

Speaking about the results, Hammami said, “The hydrophilic fraction of olive oil seems to be the effective one in reducing toxin-induced oxidative stress, indicating that hydrophilic extract may exert a direct antioxidant effect on hepatic cells. However, more detailed studies about the effect of antioxidant compounds separately and/or their interactions are necessary to substantiate these observations.”

The full article is available free online here:

Reference: Amel Nakbi, et al. Effects of olive oil and its fractions on oxidative stress and the liver’s fatty acid composition in 2,4-Dichlorophenoxyacetic acid- treated rats. Nutrition & Metabolism 2010, 7:80. October 29, 2010. doi:10.1186/1743-7075-7-80

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