Esophageal dysmotility in scleroderma: A prospective study of 183 cases
Posted Dec 21 2009 12:00am
Summary Aims
The goal of the study was to evaluate the prevalence and risk factors of esophageal motor disorders in systemic sclerosis.
Patients and methods
In 183 consecutive cases of scleroderma, as diagnosed by American College of Rheumatology criteria (1980). Patients’ mean age was 40.6 ± 13.3 years, the gender ratio was 0.13 and the average duration of disease was 6.8 ± 7.5 years. A localized, cutaneous form was observed in 148 patients (81%) and a diffuse form in 35 (19%). All patients underwent upper gastrointestinal endoscopy and standard esophageal manometry.
Results
Esophageal symptoms and reflux esophagitis were found in 108 (59%) and 68 (37%) of patients, respectively. Esophageal motor disorders were present in 148 patients (81%), and were associated with a hypotensive lower esophageal sphincter in 114 (62%). The presence of these motor abnormalities was not related to age, gender, skin extension or duration of disease. Esophageal motor disorders were present in almost all patients with esophageal symptoms or esophagitis, and were also found in 48 (64%) of the asymptomatic patients.
Conclusion
Esophageal motor disorders are frequently seen in scleroderma, especially in cases with clinical symptoms, but are not associated with a specific form of the disease.
Summary
Aims
The goal of the study was to evaluate the prevalence and risk factors of esophageal motor disorders in systemic sclerosis.
Patients and methods
In 183 consecutive cases of scleroderma, as diagnosed by American College of Rheumatology criteria (1980). Patients’ mean age was 40.6 ± 13.3 years, the gender ratio was 0.13 and the average duration of disease was 6.8 ± 7.5 years. A localized, cutaneous form was observed in 148 patients (81%) and a diffuse form in 35 (19%). All patients underwent upper gastrointestinal endoscopy and standard esophageal manometry.
Results
Esophageal symptoms and reflux esophagitis were found in 108 (59%) and 68 (37%) of patients, respectively. Esophageal motor disorders were present in 148 patients (81%), and were associated with a hypotensive lower esophageal sphincter in 114 (62%). The presence of these motor abnormalities was not related to age, gender, skin extension or duration of disease. Esophageal motor disorders were present in almost all patients with esophageal symptoms or esophagitis, and were also found in 48 (64%) of the asymptomatic patients.
Conclusion
Esophageal motor disorders are frequently seen in scleroderma, especially in cases with clinical symptoms, but are not associated with a specific form of the disease.