AbstractBy Maha F. El Goweini and Nagwa M. Nour El Din Objective:
Quercetin is a bioflavonoid noted for its antihistamine release and antiproliferative effects. These properties could theoretically prove beneficial in reversing the inflammatory and proliferative responses in hypertrophic scars. The aim of this study was to evaluate both preventive and curative effect of quercetin on animal model of hypertrophic scars.
Materials and Methods:
Full thickness four circular excisional wounds were performed on each ear of ten rabbits. Quercetin cream was applied immediately on one wound for four weeks as a preventive treatment and for eight weeks on one hypertrophic scar as a curative treatment. Placebo cream was used for the other two wounds.
Clinically, after four weeks, hypertrophic scars were developed in all non-treated and placebo-treated wounds. On the other hand, only 40% of quercetin-treated wounds healed with hypertrophic scars. The level of histamine and hydroxyproline was significantly increased in placebo-treated wounds in the preventive group. However, their levels in quercetin-treated wounds were significantly decreased. In the curative group, after eight weeks treatment with quercetin, only 20% of hypertrophic scars were flattened. While histamine level was significantly decreased in quercetin-treated scars, hydroxyproline level was insignificantly decreased as compared to placebo-treated scars.
Due to its antihistamine effect beside its antifibrotic effect, quercetin could be an effective preventive and to lesser extent an adjuvant curative treatment for hypertrophic scars.