Drug Doesn’t Significantly Lower Risk Of Major Heart Events In Patients On Dialysis
Posted Nov 03 2012 10:17pm
In one of the largest and longest trials involving patients with kidney failure, a study led by an international team of researchers found that cinacalcet — a drug commonly prescribed to patients with kidney failure and a disturbance of bone and mineral metabolism known as secondary hyperparathyroidism — does not significantly reduce the risk of death or major cardiovascular events.
The results of the trial known as EVOLVE, which enrolled nearly 4,000 kidney patients from several continents and stretched over five years, were mixed, researchers said.
“The results of the EVOLVE trial suggest that cinacalcet favorably alters bone and mineral metabolism, and could result in improved health and longevity for patients with end-stage renal disease,” said the study’s lead author, Glenn Chertow, MD, professor of medicine and chief of nephrology at the Stanford University School of Medicine. “But the trial was not definitive in determining cardiovascular benefits because so many patients discontinued taking the study drug.”