Dimeric Naphthylisoquinoline Alkaloids And Synthesis Methods Thereof
Posted Feb 27 2011 7:00pm
Description of Invention: This invention embodies novel compounds, and methods of synthesis thereof, comprising homodimeric and heterodimeric napthylisoquinoline alkaloids and derivatives. The methods presented in the invention are advantageous, for example, because they permit, for the first time, the total synthesis of compounds for which the only known natural sources are tropical plants, such as the rare Ancistrocladus korupensis of Central Africa. This class of compounds is effective in inhibiting the ability of HIV to replicate and infect cells. The compounds also have antimalarial activity. The dimeric alkaloids comprise a novel class of antiviral and antiparasitic drugs that may be very useful by themselves or in combination with other treatments.
Inventors: Gerhard Bringmann (EM) Sven Harmsen (NCI) Michael R Boyd (NCI)
For Licensing Information Please Contact: Admin. Licensing Spec-InfectDis NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: anos@mail.nih.gov Phone: 301-496-7057 Fax: 301-402-0220
Description of Invention:
This invention embodies novel compounds, and methods of synthesis thereof, comprising homodimeric and heterodimeric napthylisoquinoline alkaloids and derivatives. The methods presented in the invention are advantageous, for example, because they permit, for the first time, the total synthesis of compounds for which the only known natural sources are tropical plants, such as the rare Ancistrocladus korupensis of Central Africa. This class of compounds is effective in inhibiting the ability of HIV to replicate and infect cells. The compounds also have antimalarial activity. The dimeric alkaloids comprise a novel class of antiviral and antiparasitic drugs that may be very useful by themselves or in combination with other treatments.
Inventors:
Gerhard Bringmann (EM)
Sven Harmsen (NCI)
Michael R Boyd (NCI)
Patent Status:
HHS, Reference No. E-201-1994/0
US, , Patent No. 5,571,919, Issued 05 Nov 1996
US, , Patent No. 5,789,594, Issued 04 Aug 1998
HHS, Reference No. E-201-1994/0
Portfolios:
Infectious Diseases
Infectious Diseases - Therapeutics
For Licensing Information Please Contact:
Admin. Licensing Spec-InfectDis
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: anos@mail.nih.gov
Phone: 301-496-7057
Fax: 301-402-0220
Ref No: 229
Updated: 02/2011