Dimeric Arylisoquinoline Alkaloids And Synthesis Methods Thereof
Posted Feb 27 2011 7:00pm
Description of Invention: This invention relates to novel compounds and to a new method of chemical synthesis of known and new dimeric arylisoquinoline alkaloids. These compounds are members of a general class known as naphthylisoquinoline alkaloids. These dimeric alkaloids inhibit HIV replication in human immune cells. The compounds also have antimalarial activity. The method of this invention provides access not only to known but also heretofore unknown medically useful compounds. The invention also provides for new dimeric arylisoquinoline compounds and derivatives thereof.
For Licensing Information Please Contact: Admin. Licensing Spec-InfectDis NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: anos@mail.nih.gov Phone: 301-496-7057 Fax: 301-402-0220
Description of Invention:
This invention relates to novel compounds and to a new method of chemical synthesis of known and new dimeric arylisoquinoline alkaloids. These compounds are members of a general class known as naphthylisoquinoline alkaloids. These dimeric alkaloids inhibit HIV replication in human immune cells. The compounds also have antimalarial activity. The method of this invention provides access not only to known but also heretofore unknown medically useful compounds. The invention also provides for new dimeric arylisoquinoline compounds and derivatives thereof.
Inventors:
Michael R Boyd (NCI)
Patent Status:
HHS, Reference No. E-201-1994/1
US, , Patent No. 5,578,729, Issued 26 Nov 1996
US, , Patent No. 5,786,482, Issued 28 Jul 1998
HHS, Reference No. E-201-1994/1
Portfolios:
Infectious Diseases
Infectious Diseases - Therapeutics
For Licensing Information Please Contact:
Admin. Licensing Spec-InfectDis
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: anos@mail.nih.gov
Phone: 301-496-7057
Fax: 301-402-0220
Ref No: 273
Updated: 02/2011