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Diagnostic H5N1 Avian Influenza Virus Peptides

Posted Jul 01 2010 5:00pm

Description of Invention:
The recent spread of highly pathogenic H5N1 avian influenza viruses among poultry and transmission of these viruses to humans raises concerns of a potential influenza pandemic. There is a need to track the spread of these viruses both in the animal and human populations to avert or reduce the impact of any potential influenza pandemic as well as to know the actual number (accurate surveillance) of people infected with H5N1, including individuals with subclinical H5N1 infection.

The subject technology is a specific combination of H5N1 peptides useful for assays to detect antibodies generated against a wide range of different H5N1 strains. The combination of peptides was able to specifically detect anti-H5N1 antibodies from serum samples of H5N1 survivors at early and later times post infection while excluding antibodies generated in individuals infected with other strains of influenza virus. Also, the peptides did not react with sera from individuals vaccinated with H5N1 vaccine, in contrast to the strain-specific detection of anti-H5N1 antibodies in sera from infected individuals. Immunoassays using the H5N1 peptide combination provide highly specific, sensitive and reproducible methods for diagnosing H5N1 infection in humans and animals.

Applications:
Diagnostics for influenza virus specific antibodies in humans and animals

Advantages:
High specificity, sensitivity, and reproducibility

Development Status:
Data obtained from clinical samples can be provided upon request.

Inventors:
Hana Golding (FDA)
Surender Khurana (FDA)


Patent Status:
HHS, Reference No. E-093-2010/0
US, Application No. 61/325,073 filed 16 Apr 2010
US, Application No. 12/664,052 filed 13 Jun 2008
PCT, Application No. PCT/US2008/067001 filed 13 Jun 2008


Licensing Status:
Available for licensing.


Portfolios:
Infectious Diseases
Infectious Diseases - Diagnostics
Infectious Diseases - Vaccines
In-vitro Data



For Additional Information Please Contact:
Kevin Chang Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: changke@mail.nih.gov
Phone: 301-435-5018
Fax: 301-402-0220


Ref No: 2125

Updated: 07/2010

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