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Diagnostic and Therapeutic Methods of Detecting and Treating Cancers of Reproductive Tissues

Posted Jul 31 2007 5:00pm

Description of Invention:
PAGE-4 is a human X-linked gene that is strongly expressed in prostate and prostate cancer, and is also expressed in other male and female reproductive tissue (e.g., testis, fallopian tube, placenta, uterus, and uterine cancer). PAGE-4 shows similarity with the GAGE protein family, but it diverges significantly from members of the family so that it appears to belong to a separate family. This, and the existence of another gene, PAGE-2, that share more homology with PAGE-4 than with members of the GAGE family indicates that the PAGE-4 protein belongs to a separate protein family.

The specific detection of PAGE-4 might be valuable for the diagnosis of prostate and testicular tumors, as well as uterine tumors. There are sufficient differences between PAGE-4 and other members of the PAGE and MAGE proteins to produce specific antibodies. Analyses with such antibodies are needed to confirm by immunohistology the expression specificity that is seen in database and mRNA analyses, and to evaluate whether anti-PAGE-4 immunotherapy could be a promising therapeutic approach. One possibility of eliminating PAGE-4 expressing cells could be to use it as cancer vaccine. Among the many possible approaches to vaccination, one method is direct vaccination with plasmid DNA. In fact, Dr. Pastan’s laboratory has been able to obtain good expression of the PAGE-4 protein with mammalian expression plasmids, and has demonstrated that DNA-immunization with such expression constructs leads to good immune responses. Hence, this method may generate anti-PAGE-4 responses, and allow us to analyze if “PAGE-4-vaccination” can eliminate PAGE-4 expressing cells, as a therapeutic approach towards neoplasms of the prostate, testis, and uterus.

Ira H Pastan (NCI)
Byungkook Lee (NCI)
Ulrich Y Brinkmann (NCI)
George Vasmatzis (NCI)

Patent Status:
HHS, Reference No. E-028-1999/0
PCT, Application No. PCT/US99/20046 filed 31 Aug 1999
US, , Patent No. 7,399,827, Issued 15 Jul 2008
US, Application No. 11/704,714 filed 09 Feb 2007

Related Technologies:
US, Application No. 60/776,506 filed 24 Feb 2006, Reference No. E-104-2006/0
US, Application No. 12/280,534 filed 21 Feb 2007, Reference No. E-104-2006/0

Cancer - Diagnostics
Cancer - Therapeutics
Rare Diseases

For Additional Information Please Contact:
David Lambertson Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4632
Fax: 301-402-0220

Ref No: 1584

Updated: 08/2007

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