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Diagnosis and Treatment of Barrett's Esophagus and Associated Esophageal Adenocarcinoma

Posted Dec 31 2007 4:00pm

Description of Invention:
Barrett's esophagus is a condition in which the normal esophageal tissue lining has been replaced by an abnormal lining of gastric and intestinal tissue resulting from chronic gastroesophageal reflux disease. Patients have an increased risk of developing esophageal adenocarcinoma, which is often detected at later stages and is associated with poor prognosis. Survival rates are very low ranging from 10% in Europe to 16% in the United States.

Available for licensing are microRNA (miRNA) biomarkers that show differential expression in the adenocarcinoma diagnosis and Barrett's esophagus status, and they can predict diagnosis and Barrett's esophagus with accuracies of 71.4% and 74.7%, respectively. Thus, these miRNA biomarkers that may predispose individuals to Barrett's esophagus and/or esophageal adenocarcinoma could provide a means for earlier detection and help in better identifying treatment options.

  • Method to diagnose and treat Barrett's esophagus and esophageal adenocarcinoma.
  • miRNA pharmaceutical compositions to treat Barrett's esophagus.

Early diagnostic that can more accurately stratify patients for increased survival rates and appropriate treatments.

Development Status:
The technology is currently in the pre-clinical stage of development.

Ewy A Mathe (NCI)
Curtis C Harris (NCI)

Licensing Status:
Available for non-exclusive licensing.

Collaborative Research Opportunity:
The Laboratory of Human Carcinogenesis at the National Cancer Institute is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize methods to diagnose and treat Barrett's esophagus and esophageal carcinoma. Please contact John D. Hewes, Ph.D. at 301-435-3121 or for more information.

Cancer - Diagnostics
Cancer - Therapeutics
Cancer - Other
Gene Based Therapies
Gene Based Therapies - Diagnostics

For Additional Information Please Contact:
Jennifer Wong
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4633
Fax: 301-402-0220

Ref No: 1701

Updated: 01/2008

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