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Detection of Autoantibodies for the Diagnosis of Sjogren's Syndrome

Posted Jan 24 2010 4:00pm

Description of Invention:
This invention provides a method for diagnosing Sjogren's syndrome in a subject. In tests utilizing blood from human volunteers, this method demonstrated dramatically higher accuracy (76%) in positively diagnosing Sjogren's syndrome than a standard, currently available immunoassay (46%).

Briefly, this invention employs a panel of mammalian-derived proteins and protein fragments that are often antigentic in individuals with Sjogren's syndrome in concert with a luciferase immunoprecipitation system. In contrast, most currently available immunoassays for diagnosis of rheumatological diseases include either antigens from recombinant bacterial expression systems or single antigens from bovine sources. These immunoassays are likely to fail to present the sufficient variety of specific human epitopes that are necessary for high accuracy diagnoses of Sjogren's syndrome.

  • Diagnosis of Sjogren's syndrome.
  • A component of a panel of diagnostic tests for patients with autoimmune disease symptoms.

Higher accuracy than currently available diagnostics of Sjogren's syndrome.

Development Status:
Early stage. Initial clinical screens have been completed.

Peter D Burbelo (NIDCR)
Michael J Iadarola (NIDCR)

Patent Status:
HHS, Reference No. E-070-2009/0
US, Application No. 61/224,649 filed 10 Jul 2009

Relevant Publication:
  1. Burbelo PD, Leahy HP, Issa AT, Groot S, Baraniuk JN, Nikolov NP, Illei GG, Iadarola MJ. Sensitive and robust luminescent profiling of anti-La and other autoantibodies in Sjogren's syndrome. Autoimmunity. 2009 Sep;42(6):515-524. [ PubMed: 19657778 ]
  2. Burbelo PD, Ching KH, Issa AT, Loftus CM, Li Y, Satoh M, Reeves WH, Iadarola MJ. Rapid serological detection of autoantibodies associated with Sjögren's syndrome. J Transl Med. 2009 Sep 24;7:83. [ PubMed: 19778440 ]
  3. Burbelo PD, Ching KH, Klimavicz CM, Iadarola MJ. Antibody profiling by Luciferase Immunoprecipitation Systems (LIPS). J Vis Exp. 2009 Oct 7;(32); pii: 1549; doi: 10.3791/1549. [ PubMed: 19812534 ]

Licensing Status:
Available for licensing.

Collaborative Research Opportunity:
The National Institute of Dental and Craniofacial Research, Laboratory of Sensory Biology, Neurobiology and Pain Therapeutics Section, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize this technology. Please contact David W. Bradley, Ph.D. at 301-402-0540 or for more information.

Internal Medicine
Internal Medicine - Diagnostics

For Additional Information Please Contact:
Norbert Pontzer Ph.D., J.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 23,
Rockville, MD 20852
United States
Phone: 301-435-5502
Fax: 301-402-0220

Ref No: 2064

Updated: 01/2010

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