One of the most prevalent malignancies in the Western world, prostate cancer is often only diagnosed only after metastatic tumors have formed in other organs; in 3% of cases, these metastases are lethal. Curcumin, a spice compound extracted from the rootstalks of the turmeric plant and gives curry its yellow color and pungent flavor, has been used for centuries in folk medicine and is becoming recognized for its ability to curb the inflammatory response. In previous work, Beatrice Bachmeier, from Ludwig-Maximillians University Munchen (Germany), and colleagues established that curcumin reduces statistically significantly the formation of lung metastases in an animal model of advanced breast cancer. In the present study, the researchers aimed to investigate the efficacy of curcumin in the prevention of prostate cancer metastases, and to determine the compound’s mechanism of action. The researchers first examined the molecular processes that are abnormally regulated in prostate carcinoma cells, finding that tumor cells produce pro-inflammatory immunomodulators including the cytokines CXCL1 and CXCL2. The researchers demonstrated hat curcumin specifically decreases the expression of these two proteins, and in a mouse model, this effect correlated with a decline in the incidence of metastases. Observing that: “Chronic inflammation can induce a metastasis prone phenotype in prostate cancer cells by maintaining a positive pro-inflammatory and pro-metastatic feed-back loop between [inflammatory markers implicated in cancer],” the study authors conclude that: “Curcumin disrupts this feed-back loop by the inhibition of NFκB signalling leading to reduced metastasis formation in vivo.”
Peter H. Killian, Emanuel Kronski, Katharina Michalik, Ottavia Barbieri, Simonetta Astigiano, Beatrice E. Bachmeier, et al. “Curcumin Inhibits Prostate Cancer Metastasis in vivo by Targeting the Inflammatory Cytokines CXCL1 and -2.” Carcinogenesis, October 5, 2012.
Soccer (football outside the US) helps men with high blood pressure to improve their fitness, normalize their blood pressure. and reduce their risk of stroke.
Found in green leafy vegetables, increased consumption of phylloquinone (Vitamin K1) may lower the risk of developing type-2 diabetes by as much as 51%.
Curcumin, the spice compound that gives curry its yellow color and pungent flavor, may inhibit formation of metastases, in a lab model of prostate cancer.
A major potential source of serious infection, hospital superbugs like MRSA can float on air currents and contaminate surfaces far from infected patients’ beds.
Sitting for protracted periods of time increases risk of diabetes, heart disease, and death.
Regional (US) stroke registry data suggests that stroke may be shifting from a disease of the elderly to a mid-life health concern.
A regular exercise program that focuses on intensity of activity, rather than duration, may significantly reduce the risk of markers implicated in diabetes
By keeping the lungs healthy, people may increase their retention of cognitive functions as they age.
Lycopene, an antioxidant compound that gives tomatoes their bright color, reduces the risk of stroke by up to 55%.
Increased magnesium in the diet may reduce the risk of developing colon cancer.
Kansas State University (US) team has developed a simple blood test that can accurately detect the beginning stages of cancer.
Researchers created a membrane-bounded vesicle formed of peptides that may serve as a drug delivery system to safely treat cancer and neurodegenerative diseases
Consuming more cruciferous vegetables – such as brussels sprouts, broccoli, cauliflower, and bok choy – may slash a woman’s risk of breast cancer by 15%.
A class of drugs taken by approximately 20% of diabetics has been shown to significantly increase the risk of developing bladder cancer.
Nanoparticles, bound to compounds found in tea leaves, reduced tumors by 80%, in a lab animal model.
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Physical activity – either mild or intense and before or after menopause – may reduce breast cancer risk, but substantial weight gain may negate these benefits.
Fetal exposure to the plastic additive BPA has been shown to alter mammary gland development and plays a role in the development of breast cancer in humans.
Carvacrol, a compound found in oregano, is shown to induce prostate cancer cell death.
Swedish researchers report that cadmium, present agricultural crops as a result of farm fertilizers, is linked to an increased incidence of breast cancers.
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#70 - Chores, The Hidden Fatbuster
• House cleaning: 176-317 calories per hour
• Gardening: 352 calories per hour
• Moving furniture: 422 calories per hour
• Painting or wallpapering the house: 317 calories per hour
• Shoveling snow (by hand): 422 calories per hour
• Sweeping the driveway: 281 calories per hour