a. Systemic connective tissue diseases: (1) Scleroderma, SLE, RA, PM/DM, vasculitis, UCTD. b. Obstructive arterial diseases: Atherosclerosis, thromboangiitis obliterans. c. Occupation: Vibration, cold injury, direct arterial trauma. d. Drug-induced: Ergotamine, ß-blockers, cytotoxic drugs, oral contraceptives. e. Miscellaneous: PVC exposure, cold agglutinins, cryoglobulinemia, neoplasia, neurologic disorders, endocrinopathies. Read More about Frequency of associated conditions with Raynaud's phenomenon.