Common Anti-Inflammatory Coaxes Liver Cells To Commit Suicide
Posted May 16 2011 7:16pm
The anti-inflammatory drug celecoxib, known by the brand name Celebrex, triggers liver cancer cell death by reacting with a protein in a way that makes those cells commit suicide, according to a new study.
Researchers also found that the combination of celecoxib with each of two chemotherapy drugs killed more liver cancer cells in culture, making those combinations more effective than either drug on its own.
“Each chemotherapy drug alone will reduce the growth of cancer cells, but when each single drug is combined with Celebrex, a greater growth suppression effect was observed,” said Jiayuh Lin, senior author of the study and an associate professor of pediatrics at Ohio State University. “For clinicians, this research suggests the possibility of a new therapeutic strategy.”
The anti-inflammatory drug celecoxib, known by the brand name Celebrex, triggers liver cancer cell death by reacting with a protein in a way that makes those cells commit suicide, according to a new study.
Researchers also found that the combination of celecoxib with each of two chemotherapy drugs killed more liver cancer cells in culture, making those combinations more effective than either drug on its own.
“Each chemotherapy drug alone will reduce the growth of cancer cells, but when each single drug is combined with Celebrex, a greater growth suppression effect was observed,” said Jiayuh Lin, senior author of the study and an associate professor of pediatrics at Ohio State University. “For clinicians, this research suggests the possibility of a new therapeutic strategy.”