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Collagen-Induced Platelet Aggregation Inhibitor from Mosquito Salivary Glands

Posted Jul 30 2012 8:00pm

Description of Invention:
Exposed collagen in injured blood vessels provides a substrate for platelets to adhere and aggregate initiating the first step in thrombosis, the formation of blood clots inside a blood vessel. Despite the essential role of platelets in vascular injury, excessive platelet aggregation may also result in thrombotic diseases such as stroke and heart attack.

Available for licensing is a collagen binding protein, named aegyptin, which selectively inhibits collagen-platelet aggregation, but not platelet aggregation induced by other agonists. Collagen initiates recruitment of circulating platelets and triggers platelet activation. Collagen also plays a critical role in angiogenesis. Aegyptin blocks the interaction of collagen with its major ligands, von Willebrand factor, glycoprotein VI (GPVI), and integrin alpha2beta1. These three ligands are of particular importance because von Willebrand factor plays a critical role in tethering platelets to collagen, GPVI is the major signaling platelet receptor, and integrin alpha2beta1 mediates platelet adhesion and contributes to activation. Since these ligands play a critical role in the early stages of thrombus formation, aegyptin represents a potentially highly effective therapeutic that can prevent and treat patients with thrombotic disease. Alternatively, aegyptin is potentially useful in conditions where collagen plays a critical role in angiogenesis or in conditions where excessive deposition of collagen plays a pathological role (e.g., pancreatic carcinoma).

Applications:
  • Adjuvant to “Clot busting” therapeutics.
  • Method to prevent and/or treat cardiovascular/thrombotic disease.
  • Method to treat patients undergoing invasive cardiovascular procedures (e.g., angioplasty).
  • Model to study collagen-dependent platelet aggregation or collagen-mediated angiogenesis.


Advantages:
  • Highly effective therapeutics can negatively modulate thrombosis in its early stages by preventing collagen interaction with three major ligands involved in thrombus/clot formation.
  • Aegyptin’s potential use as a prototype for drug delivery as an oral therapeutic, which can reduce the need for invasive surgeries that dilate blood vessels such as stents or catheters.


Development Status:
Pre-clinical

Inventors:
Eric Calvo (NIAID)


Patent Status:
HHS, Reference No. E-172-2007/2
PCT, Application No. PCT/US2008/069349 filed 07 Jul 2008
US, Application No. 12/668,177 filed 07 Jan 2010


Relevant Publication:
  1. Calvo E, et al. [ PMID 17650501 ]
  2. Calvo E. Collagen-platelet aggregation inhibitor from mosquito salivary glands. Biacore T100 seminar series, November 2006, St. Louis, Missouri.
  3. Yoshida S, Watanabe H. [ PMID 16907827 ]
  4. Sun D, et al. [ PMID 16702045 ]


Collaborative Research Opportunity:
The National Institute of Allergy and Infectious Diseases, Laboratory of Malaria and Vector Research, is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize the platelet aggregation inhibitor Aegyptin. Please contact Dr. Jose Ribeiro, Head, Vector Biology Section, at 301-496-9389 or jribeiro@niaid.nih.gov for more information.


For Licensing Information Please Contact:
Patrick McCue Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: McCuepat@mail.nih.gov
Phone: 301-496-7057
Fax: 301-402-0220


Ref No: 1611

Updated: 07/2012

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