Cloning of a Genomic DNA Fragment Containing the Guinea Pig CXCR1 Gene, A Specific Receptor for Guinea Pig Interleukin-8
Posted Jun 30 2005 5:00pm
Description of Invention: e present invention relates to cloning of a genomic DNA fragment containing the guinea pig CXCR1 gene, a specific receptor for guinea pig interleukin-8 (IL-8).
More specifically, the IL-8-CXCR1 axis is a major chemokine-chemokine receptor system that regulates the recruitment of neutrophils into sites of inflammation. In this invention, the inventors cloned a genomic DNA clone containing the gene for guinea pig IL-8 receptor CXCR1. Mice and rats are the most commonly used small animals to examine the efficacy of drugs developed for human use. However, neither IL-8 nor CXCR1, a specific receptor for IL-8, is present in these animals, making it impossible to use them as a model to test the effects or IL-8 or CXCR1 antagonists. Identification of CXCR1, along with IL-8, in the guinea pig may enable evaluation of the in vivo effects of the antagonists.
Licensing Status: In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors.
Portfolios: Gene Based Therapies Gene Based Therapies - Research Materials Internal Medicine Internal Medicine - Research Materials Miscellaneous
For Additional Information Please Contact: Betty Tong Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: email@example.com Phone: 301-594-6565 Fax: 301-402-0220