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Cloning of a Genomic DNA Fragment Containing the Guinea Pig CXCR1 Gene, A Specific Receptor for Guinea Pig Interleukin-8

Posted Jun 30 2005 5:00pm

Description of Invention:
e present invention relates to cloning of a genomic DNA fragment containing the guinea pig CXCR1 gene, a specific receptor for guinea pig interleukin-8 (IL-8).

More specifically, the IL-8-CXCR1 axis is a major chemokine-chemokine receptor system that regulates the recruitment of neutrophils into sites of inflammation. In this invention, the inventors cloned a genomic DNA clone containing the gene for guinea pig IL-8 receptor CXCR1. Mice and rats are the most commonly used small animals to examine the efficacy of drugs developed for human use. However, neither IL-8 nor CXCR1, a specific receptor for IL-8, is present in these animals, making it impossible to use them as a model to test the effects or IL-8 or CXCR1 antagonists. Identification of CXCR1, along with IL-8, in the guinea pig may enable evaluation of the in vivo effects of the antagonists.

Teizo Yoshimura (NCI)

Patent Status:
HHS, Reference No. E-242-2005/0

Licensing Status:
In addition to licensing, the technology is available for further development through collaborative research opportunities with the inventors.

Gene Based Therapies
Gene Based Therapies - Research Materials
Internal Medicine
Internal Medicine - Research Materials

For Additional Information Please Contact:
Betty Tong Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-594-6565
Fax: 301-402-0220

Ref No: 1155

Updated: 07/2005

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