Description of Invention: ADP-ribosylation of arginine residues in proteins may be involved in cell adhesion and is crucial for the action of cholera toxin and E. coli heat-labile enterotoxin, agents involved in the pathogenesis of cholera and traveller's diarrhoea, respectively. ADP-ribosylation is reversed by ADP-ribosylarginine hydrolases, which cleave the ADP-ribose-arginine bond. ADP-ribosylarginine hydrolases from a variety of mammalian species and tissues were isolated, and the coding regions for the hydrolases were cloned and expressed. The availability of this new hydrolase cDNA and expression system provides a novel molecular approach for studying the role of ADP-ribosylation in cell function. The gene products may be useful in treating or preventing a variety of bacterial diseases, including cholera, that appear to be mediated via ADP-ribosylation.
Inventors: Joel Moss (NHLBI) Sally J Stanley (NHLBI) Maria S Nightingale (NHLBI) James J Murtagh (NHLBI) Lucia Monaco (NHLBI) Tatsuyuki Takada (NHLBI)
Patent Status: HHS, Reference No. E-076-1992/0
Research Tool -- Patent protection is not being pursued for this technology.
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