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Clones Encoding Mammalian ADP-Ribosylarginine Hydrolases

Posted Jan 10 2012 7:00pm

Description of Invention:
ADP-ribosylation of arginine residues in proteins may be involved in cell adhesion and is crucial for the action of cholera toxin and E. coli heat-labile enterotoxin, agents involved in the pathogenesis of cholera and traveller's diarrhoea, respectively. ADP-ribosylation is reversed by ADP-ribosylarginine hydrolases, which cleave the ADP-ribose-arginine bond. ADP-ribosylarginine hydrolases from a variety of mammalian species and tissues were isolated, and the coding regions for the hydrolases were cloned and expressed. The availability of this new hydrolase cDNA and expression system provides a novel molecular approach for studying the role of ADP-ribosylation in cell function. The gene products may be useful in treating or preventing a variety of bacterial diseases, including cholera, that appear to be mediated via ADP-ribosylation.

Joel Moss (NHLBI)
Sally J Stanley (NHLBI)
Maria S Nightingale (NHLBI)
James J Murtagh (NHLBI)
Lucia Monaco (NHLBI)
Tatsuyuki Takada (NHLBI)

Patent Status:
HHS, Reference No. E-076-1992/0

Research Tool -- Patent protection is not being pursued for this technology.

For Licensing Information Please Contact:
Tara Kirby Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-4426
Fax: 301-402-0220

Ref No: 399

Updated: 01/2012

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