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Cloned Genomes Of Infectious Hepatitis C Virus And Uses Thereof

Posted Jun 14 2010 5:00pm

Description of Invention:
The current invention provides nucleic acid sequences comprising the genomes of infectious hepatitis C viruses (HCV) of genotype 1a and 1b. It covers the use of these sequences, and polypeptides encoded by all or part of the sequences, in the development of vaccines and diagnostic assays for HCV and the development of screening assays for the identification of antiviral agents for HCV.

Additional information can be found in: Yanagi et al., "Transcripts from a single full-length cDNA clone of hepatitis C virus are infectious when directly transfected into the liver of a chimpanzee," Proc. Natl. Acad. Sci. USA (1997 August) 94(16):8738-8743; and Yanagi et al., "Transcripts of a chimeric cDNA clone of hepatitis C virus genotype 1b are infectious in vivo," Virology (25 April 1998) 244(1):161-172.

Masayuki Yanagi (NIAID)
Jens Bukh (NIAID)
Suzanne U Emerson (NIAID)
Robert H Purcell (NIAID)

Patent Status:
HHS, Reference No. E-050-1998/0
US, , Patent No. 6,153,421, Issued 28 Nov 2000
US, , Patent No. 7,201,911, Issued 10 Apr 2007
HHS, Reference No. E-050-1998/0
US, Application No. 11/784,809 filed 09 Apr 2007

Related Technologies:
EIR, Reference No. E-100-1999/0
EIR, Reference No. E-102-1999/0
EIR, Reference No. E-173-1999/0
US, Patent No. 7,084,266, Issued 01 Aug 2006, Reference No. E-100-1999/0
US, Patent No. 7,129,342, Issued 31 Oct 2006, Reference No. E-173-1999/0
PCT, Application No. PCT/US00/15527 filed 02 Jun 2000, Reference No. E-102-1999/0
US, Patent No. 7,009,044, Issued 07 Mar 2006, Reference No. E-102-1999/0
PCT, Application No. PCT/US00/15293 filed 02 Jun 2000, Reference No. E-173-1999/0
PCT, Application No. PCT/US00/15446 filed 02 Jun 2000, Reference No. E-100-1999/0

Infectious Diseases
Infectious Diseases - Therapeutics
In-vivo Data

For Additional Information Please Contact:
Kevin Chang Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-435-5018
Fax: 301-402-0220

Ref No: 347

Updated: 06/2010

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