Chinese Hamster Ovary Cells Resistant to Colcemid with Altered beta-Tubulin
Posted Mar 31 2005 4:00pm
Description of Invention: The invention is Chinese hamster ovary cells (CHO) resistant to colcemid with altered beta-tubulin. These mutants establish the essential role of tubulin in forming mitotic spindles and identify beta-tubulin as the target for colcemid toxicity.
Inventors: Michael M Gottesman (NCI) Fernando R Cabral (NCI)
Patent Status: HHS, Reference No. E-156-2004/0
Portfolios: Devices/Instrumentation Devices/Instrumentation - Research Tools and Materials Cancer Cancer - Research Materials Internal Medicine Internal Medicine - Research Materials
For Additional Information Please Contact: Surekha Vathyam Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: vathyams@mail.nih.gov Phone: 301-435-4076 Fax: 301-402-0220
Description of Invention:
The invention is Chinese hamster ovary cells (CHO) resistant to colcemid with altered beta-tubulin. These mutants establish the essential role of tubulin in forming mitotic spindles and identify beta-tubulin as the target for colcemid toxicity.
Inventors:
Michael M Gottesman (NCI)
Fernando R Cabral (NCI)
Patent Status:
HHS, Reference No. E-156-2004/0
Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Research Tools and Materials
Cancer
Cancer - Research Materials
Internal Medicine
Internal Medicine - Research Materials
For Additional Information Please Contact:
Surekha Vathyam Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: vathyams@mail.nih.gov
Phone: 301-435-4076
Fax: 301-402-0220
Ref No: 1091
Updated: 04/2005