Chimeric Peptide Antigen Library: A Novel Tool for the Development of Vaccines Against Variable Pathogens such as HIV, Tuberculo
Posted Feb 27 2011 7:00pm
Description of Invention: Many pathogens of dangerous human diseases such as HIV-1, HIV-2, viruses of hepatitis B and C, virus of influenza, viruses of dengue fever of types 1-4, pathogens of malaria and tuberculosis all possess significant variability.
Libraries of chimeric peptides, which imitate the genetic variability of the variable sections of the pathogenic protein, can cause a defensive immune response to the wide spectrum of the pathogen diversity. The immunogenic collections of chimeric peptides (libraries of variable chimeric peptides) in total reflect the natural and potential variability of the sections which determine antigenic activity.
The present invention relates to antigenic peptides, the methods of their preparation and their peptide libraries and it can be used for preparation of vaccines and medicine diagnostics. More specifically, the invention describes that the number of sequences in the library (size of library) is equal to the product of the number of possible residues in each position of peptide. The size of library can be reduced by sequential removal of residues which have the lowest frequency until the size will reach the required value.
Applications: Variable chimeric peptide libraries (VPCLs) can help construct effective vaccines capable of treating variable infectious agents such as HIV, TB, and Malaria.
VPCLs represent naturally occurring and potential variability of antigenically active regions in one vaccine.
Such VPCLs can induce production of a wide range of antibodies and cytotoxic T-lymphocytes (CTLs) with joint specificity that covers the diversity of antigenic variants of the variable infectious agent.
Development Status: Method of constructing VPCLs has been established.
Inventors: Amir Z Maksyutov (State Research Center of Virology and Biotechnolog)
For Licensing Information Please Contact: Michael Shmilovich Esq. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: email@example.com Phone: 301-435-5019 Fax: 301-402-0220