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T-cells play a critical role in the development of insulin resistance in response to a high fat diet, often leading to type-2 diabetes, but the cellular mechanism prompting the pro-inflammatory response by T-cells has been unclear. Barbara S. Nikolajczyk, from Boston University School of Medicine (Massachusetts, USA), and colleagues observed that in order for T-cells to exhibit the pro-inflammatory response, they required constant interaction with monocytes, indicating that monocytes play an indirect role in chronic inflammation and type-2 diabetes. While it is not known what the homeostatic balance levels are between pro-inflammatory and anti-inflammatory T cells, this study indicates the need to restore a balance in order to halt chronic inflammation.
Madhumita Jagannathan-Bogdan, Marie E. McDonnell, Hyunjin Shin, Qasim Rehman, Hatice Hasturk, Caroline M. Apovian, Barbara S. Nikolajczyk. “Elevated Proinflammatory Cytokine Production by a Skewed T Cell Compartment Requires Monocytes and Promotes Inflammation in Type 2 Diabetes.” J Immunol 1002615,December 17, 2010, doi:10.4049/jimmunol.1002615.