Cell Line PE, Developed From Mouse Skin Tumors, Demonstrates Unique Qualities
Posted Feb 29 2008 4:00pm
Description of Invention: Available for licensing is the mouse skin tumor cell line PE. These skin tumor cells were isolated from papilloma cells induced by chemical carcinogens. The PE cell lines differ from normal keratinocytes in their ability to maintain a proliferating population under conditions favoring terminal differentiation, their consistent proliferative response to phorbol esters under these same conditions, and their reduced sensitivity to phorbol ester-induced terminal differentiation. All of these properties should provide a growth advantage to these cells during tumor promotion. The PE cell line is one of the studied cell lines.
The PE cell lines could be used for assays for cancer treatment and prevention or study of several aspects of cutaneous biology.
PE cells could be used in the cosmetic industry to study response to cosmaceuticals or fragrances.
PE cells also demonstrated robust expression of phase 2 detoxification enzymes in response to a variety of inducing agents.
Advantages: The various properties of papilloma cells (PE cell line) differ from keratinocytes which will provide a growth advantage to the PE cell lines during tumor promotion.
Patent Status: Research Tool -- patent protection is not being sought for this technology
SH Yuspa et al. Cultivation and characterization of cells derived from mouse skin papillomas induced by an initiation-promotion protocol. Carcinogenesis 1986 Jun;7(6):949-958. [ PubMed abs ]
Licensing Status: Available for non-exclusive licensing.
Portfolios: Cancer Cancer - Research Materials Internal Medicine Internal Medicine - Diagnostics Internal Medicine - Therapeutics
For Additional Information Please Contact: Patrick McCue Ph.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325, Rockville, MD 20852 United States Email: McCuepat@mail.nih.gov Phone: 301-496-7057 Fax: 301-402-0220