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Cell-Free Assembly of Lentiviral Capsids

Posted Jun 02 2010 5:00pm

Description of Invention:
Dr. Campbell and his colleagues have discovered a novel method of assembling HIV immature capsids from recombinant purified Gag proteins in vitro. Specifically, the discovery is that the presence of certain phosphates is required for assembly of full-sized HIV capsids in vitro. Therefore, compounds which interfere with the effect of these phosphates on virus assembly or that deplete cellular pools of these phosphates, could be effective antiviral agents. This discovery then provides an in vitro screening method of identifying such potential antiviral agents. It also provides techniques for producing full-size virus-like particles in vitro. In fact, Dr. Campbell is the first to report the assembly of authentic viral capsids from full length Gag proteins in a completely defined system. Such proteins could be potentially useful as safe HIV vaccines or for delivery of nucleic acids or pharmacological agents in patients.

No Inventor Information Available.

Patent Status:
HHS, Reference No. E-287-2000/0

Infectious Diseases
Infectious Diseases - Vaccines
In-vitro Data

For Additional Information Please Contact:
Admin. Licensing Spec-InfectDis
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Phone: 301-496-7057
Fax: 301-402-0220

Ref No: 225

Updated: 06/2010

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