Description of Invention: Dr. Campbell and his colleagues have discovered a novel method of assembling HIV immature capsids from recombinant purified Gag proteins in vitro. Specifically, the discovery is that the presence of certain phosphates is required for assembly of full-sized HIV capsids in vitro. Therefore, compounds which interfere with the effect of these phosphates on virus assembly or that deplete cellular pools of these phosphates, could be effective antiviral agents. This discovery then provides an in vitro screening method of identifying such potential antiviral agents. It also provides techniques for producing full-size virus-like particles in vitro. In fact, Dr. Campbell is the first to report the assembly of authentic viral capsids from full length Gag proteins in a completely defined system. Such proteins could be potentially useful as safe HIV vaccines or for delivery of nucleic acids or pharmacological agents in patients.
Inventors: No Inventor Information Available.
Patent Status: HHS, Reference No. E-287-2000/0
Portfolios: Infectious Diseases Infectious Diseases - Vaccines In-vitro Data