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cDNA for Murine PEDF

Posted Nov 30 2004 4:00pm

Description of Invention:
This technology is a cDNA, obtained from mouse liver, which encodes the open reading frame of the murine homolog of pigment epithelium-derived factor (mPEDF). PEDF is a serpin protein that has not been demonstrated to have serine protease activity in a physiological setting but which exhibits diverse biologic properties including neurotrophic activity and anti-angiogenic activity. The mPEDF cDNA may be used to study PEDF function and may be particularly useful in research applications comparing mPEDF to hPEDF. The cDNA, provided as a plasmid designated pMOU12A, can be readily inserted into an expression vector.

Ignacio R Rodriguez (NEI)
Vijay K Singh (NEI)
Gerald J Chader (NEI)

Patent Status:
Research Tool -- patent prosecution is not being pursued for this technology

Relevant Publication:
  1. VK Singh et al. Structural and comparative analysis of the mouse gene for pigment epithelium-derived factor (PEDF). Mol Vis. 1998 Apr 20;4:7. [ PubMed abs ]

Licensing Status:
The cDNA is available through a biological materials license agreement.

Devices/Instrumentation - Research Tools and Materials
Cancer - Research Materials
Internal Medicine
Internal Medicine - Research Materials

For Additional Information Please Contact:
Susan Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 30A,
Rockville, MD 20852
United States
Phone: 301-435-4478
Fax: 301-402-0220

Ref No: 1006

Updated: 12/2004

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