Description of Invention: This technology is a cDNA, obtained from mouse liver, which encodes the open reading frame of the murine homolog of pigment epithelium-derived factor (mPEDF). PEDF is a serpin protein that has not been demonstrated to have serine protease activity in a physiological setting but which exhibits diverse biologic properties including neurotrophic activity and anti-angiogenic activity. The mPEDF cDNA may be used to study PEDF function and may be particularly useful in research applications comparing mPEDF to hPEDF. The cDNA, provided as a plasmid designated pMOU12A, can be readily inserted into an expression vector.
Inventors: Ignacio R Rodriguez (NEI) Vijay K Singh (NEI) Gerald J Chader (NEI)
Patent Status: Research Tool -- patent prosecution is not being pursued for this technology
Relevant Publication:
VK Singh et al. Structural and comparative analysis of the mouse gene for pigment epithelium-derived factor (PEDF). Mol Vis. 1998 Apr 20;4:7. [ PubMed abs ]
Licensing Status: The cDNA is available through a biological materials license agreement.
Portfolios: Devices/Instrumentation Devices/Instrumentation - Research Tools and Materials Cancer Cancer - Research Materials Internal Medicine Internal Medicine - Research Materials
For Additional Information Please Contact: Susan Rucker J.D. NIH Office of Technology Transfer 6011 Executive Blvd. Suite 325
Room 30A, Rockville, MD 20852 United States Email: ruckersu@mail.nih.gov Phone: 301-435-4478 Fax: 301-402-0220
Description of Invention:
This technology is a cDNA, obtained from mouse liver, which encodes the open reading frame of the murine homolog of pigment epithelium-derived factor (mPEDF). PEDF is a serpin protein that has not been demonstrated to have serine protease activity in a physiological setting but which exhibits diverse biologic properties including neurotrophic activity and anti-angiogenic activity. The mPEDF cDNA may be used to study PEDF function and may be particularly useful in research applications comparing mPEDF to hPEDF. The cDNA, provided as a plasmid designated pMOU12A, can be readily inserted into an expression vector.
Inventors:
Ignacio R Rodriguez (NEI)
Vijay K Singh (NEI)
Gerald J Chader (NEI)
Patent Status:
Research Tool -- patent prosecution is not being pursued for this technology
Relevant Publication:
Licensing Status:
The cDNA is available through a biological materials license agreement.
Portfolios:
Devices/Instrumentation
Devices/Instrumentation - Research Tools and Materials
Cancer
Cancer - Research Materials
Internal Medicine
Internal Medicine - Research Materials
For Additional Information Please Contact:
Susan Rucker J.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325 Room 30A,
Rockville, MD 20852
United States
Email: ruckersu@mail.nih.gov
Phone: 301-435-4478
Fax: 301-402-0220
Ref No: 1006
Updated: 12/2004