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cDNA Encoding a Gene BOG and its Protein Product

Posted Jun 15 2010 5:00pm

Description of Invention:
Available for licensing is BOG (B5t Over-Expressed Gene) with the gene product pRb of the well-known tumor suppressor gene RB, retinoblastoma susceptibility gene. The complex formed between Rb and BOG typically does not contain E2F-1 in vivo. This binding property suggests that cells which are transformed/transfected with cDNA or other functional nucleotide sequences which encode the BOG gene product will be useful as tools for studying cell cycle control and oncogenesis.

Studies using rat liver epithelial cell (RLE) lines which are resistant to the growth inhibitory effects of TGF-beta1 and primary liver tumors have been shown to over-express BOG. Moreover, when normal RLE continuously over-express BOG the cells become transformed and the transformed cells are able to form hepatoblastoma-like tumors when transplanted into nude mice. Therefore, biologics derived from BOG may be useful as diagnostics or therapeutics.

Applications:
  • Method to diagnose and treat liver cancer
  • Method to study cell cycle control and oncogenesis
  • Liver cancer therapeutics


Development Status:
The technology is currently in the pre-clinical stage of development.

Inventors:
Snorri S Thorgeirsson (NCI)


Relevant Publication:
  1. JT Woitach et al. A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability. Nat Genet. 1998 Aug;19(4):371-374. [ PubMed abs ]


Licensing Status:
Available for licensing.

Collaborative Research Opportunity:
The National Cancer Institute (NCI), Center for Cancer Research, Laboratory of Experimental Carcinogenesis is seeking statements of capability or interest from parties interested in collaborative research to further develop, evaluate, or commercialize of BOG (B5t Over-Expressed Gene) with the gene product pRb. Please contact John Hewes, Ph.D. at the NCI Technology Transfer Center at hewesj@mail.nih.gov or (301) 496-0477 for more information.


Portfolios:
Cancer
Cancer - Diagnostics
Cancer - Therapeutics
Cancer - Research Materials
Cancer - Other
In-vivo Data



For Additional Information Please Contact:
Jennifer Wong
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: wongje@mail.nih.gov
Phone: 301-435-4633
Fax: 301-402-0220


Ref No: 39

Updated: 06/2010

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