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Cancer-linked Sequences Encoding the A2BP1/ FOX1 Gene

Posted Oct 28 2010 8:00pm

Description of Invention:
Mesothelioma is a rare type of cancer in which malignant cells are found in the lining of the chest or abdomen. Symptoms are frequently misdiagnosed and an accurate diagnosis generally does not occur until advanced stages, and patients live on average nine to thirteen months after an accurate diagnosis. To date, there are no effective systemic treatments.

Researchers at the National Cancer Institute, NIH, have identified a recurrent alteration in the DNA sequence for ataxin-2 binding protein (A2BP1/ FOX1) in human mesothelioma and colorectal cancers that is present in at least twenty percent (20%) of cancer cell lines and primary tumor samples. The sequence is not present in normal tissue, proving that it has arisen as an acquired somatic mutation in cancer. Furthermore, additional data suggests a possible role for the alteration in neurological diseases such as autism, inherited mental retardation, and seizures.

This discovery offers a new approach for the diagnosis and early detection of cancer.

Applications:
Development of assays for detection, diagnosis, or prognosis of diseases associated with chromosomal disruptions of the ataxin-2 binding protein 1 (A2BP1 or FOX1) gene, such as cancer and neurological disorders.

Development Status:
Pre-clinical

Inventors:
Frederic J Kaye (NCI)


Patent Status:
HHS, Reference No. E-180-2008/0
PCT, Application No. PCT/US09/67502 filed 10 Dec 2009 , which published as WO 2010/068757 on 17 Jun 2010


Relevant Publication:
  1. Beroukhim R et al. The landscape of somatic copy-number alteration across human cancers. Nature 2010 Feb 18; 463(7283):899-905. [ PubMed: 20164920 ]


Licensing Status:
Available for licensing.


Portfolios:
Cancer
Cancer - Diagnostics
Cancer - Therapeutics
Gene Based Therapies
Gene Based Therapies - Diagnostics
Central Nervous System
Central Nervous System - Diagnostics
Central Nervous System - Therapeutics



For Licensing Information Please Contact:
Patrick McCue Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: McCuepat@mail.nih.gov
Phone: 301-496-7057
Fax: 301-402-0220


Ref No: 2186

Updated: 10/2010

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