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Cancer Drug Combats Alzheimer’s Disease

Posted Jul 07 2013 10:08pm

The drug bexarotene is approved by the US Food and Drug Administration for use in cutaneous T cell lymphoma.  Rada Koldamova, from the University of Pittsburgh Graduate School of Public Health (Pennsylvania, USA), and colleagues report that bexarotene significantly improves cognitive deficits, in a mouse model of Alzheimer's Disease. The team demonstrated that bexarotene decreased the amyloid beta peptides present in the interstitial fluid that surrounds brain cells.  The mice with the Alzheimer's gene mutations expressing human APOE3 or APOE4 were able to perform as well in cognitive tests as their non-Alzheimer's counterparts 10 days after beginning treatment with bexarotene.

Fitz NF, Cronican AA, Lefterov I, Koldamova R. “Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models".  Science. 2013 May 24;340(6135):924-c.`

  
Bexarotene reverses memory deficits, in an Alzheimer's disease mouse model.
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Alzheimer’s Disease presently afflicts 5.2 million Americans with the number swelling to 13.8 million by 2050
Worse sleep quality may correlate to increased amyloid deposits in the brain, a marker of Alzheimer's Disease.
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Low serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 may correlate with Alzheimer's Disease, in men
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Tip #185 - The Cold Facts
A number of studies have suggested a role for vitamin D in innate immunity, including the prevention of respiratory tract infections (RTIs). Researchers from the University of Colorado (Colorado, USA) analyzed data from the Third National Health and Nutrition Examination Survey, which involved 18,883 adults and adolescents between 1988 and 1994. The team found that people with the lowest average levels of Vitamin D in the blood were about 40% more likely to have a recent RTI, as compared to those with the highest Vitamin D blood levels . Further, low Vitamin D levels in people with asthma were associated with a five-time greater risk of RTI; and among COPD patients, RTIs were twice as common among those with Vitamin D deficiency.

Therapeutic Daily Dosing: Consult an anti-aging physician to determine the dosing that is appropriate for your medical needs.
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