The drug bexarotene is approved by the US Food and Drug Administration for use in cutaneous T cell lymphoma. Rada Koldamova, from the University of Pittsburgh Graduate School of Public Health (Pennsylvania, USA), and colleagues report that bexarotene significantly improves cognitive deficits, in a mouse model of Alzheimer's Disease. The team demonstrated that bexarotene decreased the amyloid beta peptides present in the interstitial fluid that surrounds brain cells. The mice with the Alzheimer's gene mutations expressing human APOE3 or APOE4 were able to perform as well in cognitive tests as their non-Alzheimer's counterparts 10 days after beginning treatment with bexarotene.
Fitz NF, Cronican AA, Lefterov I, Koldamova R. “Comment on "ApoE-directed therapeutics rapidly clear β-amyloid and reverse deficits in AD mouse models". Science. 2013 May 24;340(6135):924-c.`
Bexarotene reverses memory deficits, in an Alzheimer's disease mouse model.
Cognition and arterial aging both may benefit from daily supplements of curcumin.
After being diagnosed with prostate cancer, men who eat a diet high in vegetable fats, such as those in nuts and olive oil, may be less likely to have their dis
Daily supplements of calcium up to 1000 mg may reduce mortality, among women.
In four out of ten cases, long-term psychological stress leads to some form of physical ailment, among middle-aged women.
“Heading” a soccer ball may cause trauma to the brain that can cause memory loss.
The molecule microRNA-146a (miR-146a) acts as a critical regulator and protector of hematopoietic stem cells, or HSCs) during chronic inflammation.
Increased circulating levels of magnesium may help to reduce the risk of cardiovascular disease by up to 30%.
As compared to people whose diets include meats, fish, and eggs, those who consume a plant-based diet have lower rates of both death and diseases.
Coenzyme Q10 may reduce mortality rates due to heart failure by half.
Researchers successfully grow a key type of human brain cell in the laboratory, and successfully transplant it for further maturation in the brains of mice.
A drug that controls type-2 diabetes may help to repair spinal cords affected by inherited neurodegenerative disease, in a mouse model.
Alzheimer’s Disease presently afflicts 5.2 million Americans with the number swelling to 13.8 million by 2050
Worse sleep quality may correlate to increased amyloid deposits in the brain, a marker of Alzheimer's Disease.
People who maintain cardiorespiratory fitness in mid-life may be less likely to develop dementia and Alzheimer’s Disease, as they age.
Higher vitamin D dietary intake associates with a lower risk of developing Alzheimer's disease, among women.
An active lifestyle helps preserve gray matter in the brains of older adults and could reduce the burden of dementia and Alzheimer's disease.
Salk Institute (US) scientists reveal a physiological mechanism that may link diabetes to Alzheimer's Disease.
Eating a diet laden with carbohydrates raises the risk of developing mild cognitive impairment by four times; sugars raise that risk 1.5 times.
Low serum levels of insulin-like growth factor-1 and insulin-like growth factor binding protein-3 may correlate with Alzheimer's Disease, in men
Tip #185 - The Cold Facts
A number of studies have suggested a role for vitamin D in innate immunity, including the prevention of respiratory tract infections (RTIs). Researchers from the University of Colorado (Colorado, USA) analyzed data from the Third National Health and Nutrition Examination Survey, which involved 18,883 adults and adolescents between 1988 and 1994. The team found that people with the lowest average levels of Vitamin D in the blood were about 40% more likely to have a recent RTI, as compared to those with the highest Vitamin D blood levels . Further, low Vitamin D levels in people with asthma were associated with a five-time greater risk of RTI; and among COPD patients, RTIs were twice as common among those with Vitamin D deficiency.
Therapeutic Daily Dosing: Consult an anti-aging physician to determine the dosing that is appropriate for your medical needs.