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Cancer Changes Cell Metabolism

Posted May 24 2013 10:08pm
Posted on May 21, 2013, 6 a.m. in Genetics in Disease Cancer Diagnostics

Via gene expression data analysis, Denis Vitkup, from Columbia University Medical Center (New York, USA), and colleagues have identified hundreds of new potential targets in the early detection and treatment of cancer.  The team found that cancer-induced changes in metabolism are significantly different in various types of tumors. Reporting that there are no single and universal changes in cancer metabolism, the investigators submit that researchers need to consider how different tumor types adapt their metabolism to meet their specific needs, thus targeting metabolism may be a way to strike cancer at its roots.  The study authors write that: “. On the level of individual biochemical reactions, many hundreds of metabolic isoenzymes show significant and tumor-specific expression changes. These isoenzymes are potential targets for anticancer therapy.”

Jie Hu, Jason W Locasale, Jason H Bielas, Jacintha O'Sullivan, Kieran Sheahan, et al.  “Heterogeneity of tumor-induced gene expression changes in the human metabolic network.”  Nature Biotechnology, 21 April 2013.

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Tip #167 - Snooze, Don’t Lose
Too little sleep compromises many of the body’s biological processes, most notably the immune system, metabolic function, and cognitive performance (specifically, learning and memory). Researchers from Beth Israel Deaconess Medical Center (Massachusetts, USA) reported that sleep is important for the development of episodic memories, and particularly those of an emotional nature. The team studied 88 college students, and found that those subjects who slept a full evening remembered the emotional scene they were shown in far greater detail, as compared to those participants who stayed awake for 12 hours after viewing the scene.

Defying the adage that ‘you snooze, you lose,’ sleep is a vital process that helps to preserve memories. Don’t underestimate the restorative role of sleep: while the amount of sleep required is highly individualized, it is critical to get sleep of a sufficient duration that is followed by a spontaneous awakening and leaves you feeling refreshed and alert for the day.

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