Health knowledge made personal
Daily supplementation of folic acid and vitamin B12 help to improve brain functioning among older people.
A new way to deliver therapeutic human cells to diseased areas paves the way towards effectively using cell therapy to treat a variety of disorders.
DHEA (dehydroepiandrosterone), a hormone secreted by the adrenal glands, helps to alleviate menopausal symptoms.
Women who are at risk for breast cancer may also be at greater risk for heart disease.
Baylor College of Medicine (US) team reports that in a mouse model, mice learn and remember better when activity of a molecule known as PKR is inhibited in the
Higher levels cadmium, lead, and arsenic in the body associate with an increased risk of pancreatic cancer, whereas elevated levels of selenium and nickel assoc
Acupuncture significantly reduces levels of neuropeptide Y, a marker of chronic stress, in a lab animal model.
Italian researchers reveal that a molecule known as CREB1 is triggered by a low-calorie diet and promotes a healthy brain, in a lab animal model.
Mindfulness techniques reduce psychological distress and fatigue in people experiencing inflammatory rheumatic joint diseases.
A number of research groups are developing DNA-based circuits designed to be embedded in the human body, to monitor health and treat diseases before...
January 2012
27–29
Fellowship in Anti-Aging, Regenerative & Functional Medicine:
Module XX
February
24–26
Fellowship in Anti-Aging, Regenerative & Functional Medicine:
Module III, VII or XIV(B)
March
22–24
Fellowship in Anti-Aging, Regenerative & Functional Medicine:
Module II or VI or XIV
April
May
|
Write a comment:
|
Women who are at risk for breast cancer may also be at greater risk for heart disease, report researchers from St. Michael's Hospital (Canada). Observing that the majority of women with hereditary breast and ovarian cancer have a mutated form of the BRCA1 or BRCA2 genes, which normally suppress the growth of breast and ovarian tumors, Subodh Verma and colleagues have discovered that the genes also regulate heart function. Following a heart attack, mice with the mutated BRCA1 gene had a three-to-five times higher rate of death. This was largely due to the development of profound heart failure, possibly because their heart attacks were twice as severe as those in mice who did not have the mutated gene. A similar two-fold increase in heart failure was observed when mice with a mutated BRCA1 or BRAC2 gene were treated with doxorubicin, one of the most common chemotherapy drugs for patients with breast cancer. In addition to studies in mice, the authors also verified this observation in human tissues. The researchers believe that the mutated BRCA1/2 prevents DNA repair in muscle cells that is essential to recovery after a heart attack. Submitting that: “These data reveal BRCA1 as a novel and essential adaptive response molecule shielding cardiomyocytes from DNA damage, apoptosis and heart dysfunction,” the study authors conclude that: “BRCA1 mutation carriers, in addition to risk of breast and ovarian cancer, may be at a previously unrecognized risk of cardiac failure.”
Praphulla C. Shukla, Krishna K. Singh, Adrian Quan, Mohammed Al-Omran, Hwee Teoh, Subodh Verma, et al. “BRCA1 is an essential regulator of heart function and survival following myocardial infarction.” Nature Communications 2, 20 Dec. 2011.