Botox shows promise for incontinence in MS patients
Posted Jun 18 2011 6:49am
People with m ultiple sclerosis (MS) or spinal cord injury may benefit from botox injections, as the treatment may help to ease the urinary incontinence that sometimes accompanies these conditions.
A total of 416 patients were given injections of the treatment, called OnabotulinumtoxinA, or a placebo (dummy treatment) and were followed for up to 64 weeks to see if there was any improvement in their need for incontinence supplies .
The results of the phase-III trial show that the drug was associated with a significant decrease in episodes of urinary incontinence in this group of patients.
Before treatment, participants typically reported at least 14 episodes of adult incontinence per week.
After six weeks of treatment, 36 per cent of patients on the lower dose and 41 per cent of patients on the higher dose of botox reported that they were no longer experiencing any incontinence .
Dr Matthew Fraser, adjunct assistant professor of urology and research physiologist at Duke University and the Durham VA Medical Centre in North Carolina, told Medscape Medical News: “About 40 per cent of patients with spinal cord impairment and multiple sclerosis have urinary incontinence.”
The expert added that the study results, which were presented at the annual scientific meeting of the American Urological Association, were “for the most part impressive”.
A urologist at the Hamad Medical Corporation in Qatar, Dr Ardalan Abdolghafor Ghafouri, recently told the Gulf Times that botox injections can be useful for treating urinary incontinence caused by an overactive bladder.