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Bone Morphogenetic Variants, Compositions and Methods of Treatment

Posted Jun 02 2010 5:00pm

Description of Invention:
The invention identifies proteins belonging to TGF-Beta superfamily that promote repair of menisci, cruciate and collateral ligaments of the knee, and rotator cuff tendons. The application claims nucleic acids encoding human Cartilage-Derived Morphogenetic Protein-1 (hCDMP-1) variant polypeptides. Morphogenetic proteins are able to induce the proliferation and differentiation of progenitor cells into functional bone, cartilage, tendon, or ligament tissue.

Inventors:
Malcolm C Moos (FDA)
John T Thomas (FDA)


Patent Status:
HHS, Reference No. E-196-2004/0
US, Application No. 11/916,990 filed 08 Jul 2006


Licensing Status:
Available for licensing.


Portfolios:
Gene Based Therapies
Gene Based Therapies - Therapeutics
Internal Medicine
Internal Medicine - Therapeutics
Miscellaneous



For Additional Information Please Contact:
Surekha Vathyam Ph.D.
NIH Office of Technology Transfer
6011 Executive Blvd. Suite 325,
Rockville, MD 20852
United States
Email: vathyams@mail.nih.gov
Phone: 301-435-4076
Fax: 301-402-0220


Ref No: 1335

Updated: 06/2010

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